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Term:
protein disulfide isomerase activity (GO:0003756)
Annotations: Rat: (17) Mouse: (18) Human: (22) Chinchilla: (7) Bonobo: (7) Dog: (16) Squirrel: (7) Pig: (16)
Parent Terms Term With Siblings Child Terms
[acyl-carrier-protein] phosphodiesterase activity 
[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase 
[protein-PII] uridylyltransferase activity 
alpha-1,4-glucan-protein synthase (ADP-forming) activity 
biotin-protein ligase activity +   
catalytic activity, acting on a glycoprotein +   
deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity 
dihydrolipoyllysine-residue acetyltransferase activity  
dihydrolipoyllysine-residue succinyltransferase activity  
lipoate-protein ligase activity  
microtubule plus end polymerase  
microtubule-severing ATPase activity  
palmitoyl-(protein) hydrolase activity  
peptidase activity +   
peptide alpha-N-propionyltransferase activity 
peptide-aspartate beta-dioxygenase activity  
peptide-O-fucosyltransferase activity  
peptide-tryptophan 2,3-dioxygenase activity 
peptidyl-arginine 3-dioxygenase activity 
peptidyl-asparagine 3-dioxygenase activity  
peptidyl-aspartic acid 3-dioxygenase activity  
peptidyl-cysteine S-nitrosylase activity  
peptidyl-histidine dioxygenase activity  
peptidyl-lysine 3-dioxygenase activity 
peptidyl-lysine 4-dioxygenase activity 
peptidyl-lysine 5-dioxygenase activity +   
peptidyl-lysine N6-palmitoyltransferase activity 
peptidyl-proline dioxygenase activity +   
peptidyl-prolyl cis-trans isomerase activity  
peptidylamidoglycolate lyase activity  
phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity 
phosphoprotein phosphatase activity +   
polypeptide N-acetylgalactosaminyltransferase activity  
procollagen galactosyltransferase activity  
procollagen glucosyltransferase activity  
protein adenylylhydrolase activity  
protein ADP-ribosylase activity  
protein deacetylase activity +   
protein deglycase activity  
protein demethylase activity +   
protein disulfide isomerase activity  
Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
protein kinase activity +   
protein methylesterase activity +   
protein methylthiotransferase activity 
protein methyltransferase activity +   
protein N-acetylglucosaminyltransferase activity  
protein O-GlcNAc transferase activity  
protein prenyltransferase activity +   
protein xylosyltransferase activity  
protein-cysteine S-acyltransferase activity +   
protein-fructosamine 3-kinase activity  
protein-glucosylgalactosylhydroxylysine glucosidase activity  
protein-glutamic acid ligase activity +   
protein-glycine ligase activity +   
protein-lysine 6-oxidase activity  
protein-ribulosamine 3-kinase activity  
protein-tyrosine sulfotransferase activity  
Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity 
transferase activity, transferring amino-acyl groups +   
tubulin-tyrosine ligase activity  
ubiquitin-like protein transferase activity +   
ubiquitinyl hydrolase activity +   

Synonyms
Exact Synonyms: disulphide bond biosynthesis ;   disulphide bond formation ;   protein disulphide isomerase activity ;   protein thiol-disulfide exchange ;   protein thiol-disulphide exchange
Broad Synonyms: protein disulfide-isomerase
Related Synonyms: S-S rearrangase activity ;   protein cysteine-thiol oxidation ;   protein disulfide-isomerase reaction
Alternate IDs: GO:0006467
Xrefs: EC:5.3.4.1 ;   MetaCyc:5.3.4.1-RXN ;   reactome:R-HSA-8950113 "IL12A binds IL12B" ;   reactome:R-HSA-8950183 "IL12B binds IL23A" ;   reactome:R-HSA-8950456 "IL12B dimerizes"
Definition Sources: EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.