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Ontology Browser

Term:
arachidonate 12(S)-lipoxygenase activity (GO:0004052)
Annotations: Rat: (4) Mouse: (4) Human: (3) Chinchilla: (2) Bonobo: (3) Dog: (3) Squirrel: (2) Pig: (3)
Parent Terms Term With Siblings Child Terms
1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity 
1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity 
1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity 
1-hydroxy-2-naphthoate 1,2-dioxygenase activity 
2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity 
2,2',3-trihydroxybiphenyl dioxygenase activity 
2,3-dihydroxy DDT 1,2-dioxygenase activity 
2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity 
2,3-dihydroxy-p-cumate dioxygenase activity 
2,3-dihydroxybenzoate 2,3-dioxygenase activity 
2,3-dihydroxybenzoate 3,4-dioxygenase activity 
2,3-dihydroxybiphenyl 1,2-dioxygenase activity 
2,3-dihydroxydiphenyl ether dioxygenase activity 
2,3-dihydroxyindole 2,3-dioxygenase activity 
2,4'-dihydroxyacetophenone dioxygenase activity 
2,5-dihydroxypyridine 5,6-dioxygenase activity 
2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity 
2-aminophenol 1,6-dioxygenase activity 
2-mercaptobenzothiazole dioxygenase activity 
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity 
3,4-dihydroxyphenanthrene dioxygenase activity 
3,4-dihydroxyphenylacetate 2,3-dioxygenase activity 
3,5-dichlorocatechol 1,2-dioxygenase activity 
3-carboxyethylcatechol 2,3-dioxygenase activity 
3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity 
3-hydroxy-2-naphthoate 2,3-dioxygenase activity 
3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity 
3-hydroxyanthranilate 3,4-dioxygenase activity  
4,5-dihydroxybenzo(a)pyrene dioxygenase activity 
4,5-dihydroxypyrene dioxygenase activity 
4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity 
4-hydroxycatechol 1,2-dioxygenase activity 
4-hydroxymandelate synthase activity 
4-hydroxyphenylpyruvate dioxygenase activity  
5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity 
5,6-dimethylbenzimidazole synthase activity 
5-aminosalicylate dioxygenase activity 
7,8-dihydroxy benzo(a)pyrene dioxygenase activity 
7,8-dihydroxykynurenate 8,8a-dioxygenase activity 
9,10-dihydroxybenzo(a)pyrene dioxygenase activity 
9-cis-10'-apo-beta-carotenal cleavage oxygenase activity 
9-cis-beta-carotene 9',10'-cleavage oxygenase activity 
acetylacetone-cleaving enzyme activity 
acireductone dioxygenase (Ni2+-requiring) activity 
acireductone dioxygenase [iron(II)-requiring] activity  
all-trans-8'-apo-beta-carotenal 15,15'-oxygenase 
all-trans-beta-apo-10'-carotenal cleavage oxygenase activity 
arachidonate 12(R)-lipoxygenase activity 
arachidonate 12(S)-lipoxygenase activity  
Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.
arachidonate 15-lipoxygenase activity  
arachidonate 5-lipoxygenase activity  
arachidonate 8(R)-lipoxygenase activity  
arachidonate 8(S)-lipoxygenase activity  
benzo(a)pyrene 11,12-dioxygenase activity 
benzo(a)pyrene 4,5-dioxygenase activity 
benzo(a)pyrene 7,8-dioxygenase activity 
benzo(a)pyrene 9,10-dioxygenase activity 
beta,beta-carotene-9',10'-cleaving oxygenase activity  
beta-carotene 15,15'-monooxygenase activity  
beta-carotene oxygenase activity 
biphenyl-2,3-diol 1,2-dioxygenase activity 
caffeate 3,4-dioxygenase activity 
carbazole 1,9a-dioxygenase activity 
carotenoid dioxygenase activity +   
catechol dioxygenase activity +  
chloridazon-catechol dioxygenase activity 
chlorite O2-lyase activity 
chlorocatechol 1,2-dioxygenase activity 
cysteamine dioxygenase activity  
cysteine dioxygenase activity  
dihydroxydibenzothiophene dioxygenase activity 
dihydroxyfluorene dioxygenase activity +  
diphenyl ether 1,2-dioxygenase activity 
fatty acid alpha-oxygenase activity 
gallate dioxygenase activity 
gentisate 1,2-dioxygenase activity 
homogentisate 1,2-dioxygenase activity  
hydroquinone 1,2-dioxygenase activity 
hydroxyquinol 1,2-dioxygenase activity 
indole 2,3-dioxygenase activity 
indoleamine 2,3-dioxygenase activity  
lignostilbene alpha beta-dioxygenase activity 
linoleate 11-lipoxygenase activity 
linoleate 13S-lipoxygenase activity  
linoleate 8R-lipoxygenase 
linoleate 8R-lipoxygenase activity 
linoleate 9R-lipoxygenase activity 
linoleate 9S-lipoxygenase activity  
linolenate 9R-lipoxygenase activity 
lutein oxygenase activity 
p-cumate 2,3-dioxygenase activity 
peptide-tryptophan 2,3-dioxygenase activity 
phenanthrene dioxygenase activity 
phenanthrene-4-carboxylate dioxygenase activity 
protocatechuate 3,4-dioxygenase activity 
protocatechuate 3,4-dioxygenase type II activity 
protocatechuate 4,5-dioxygenase activity 
pyrene dioxygenase activity 
pyridine-3,4-diol dioxygenase activity 
pyrogallol 1,2-oxygenase activity 
quercetin 2,3-dioxygenase activity  
stizolobate synthase activity 
stizolobinate synthase activity 
styrene dioxygenase activity 
sulfur dioxygenase activity  
sulfur oxygenase/reductase activity 
tetrachlorobenzene dioxygenase activity 
tryptophan 2,3-dioxygenase activity  
violaxanthin oxygenase activity 

Synonyms
Exact Synonyms: 12Delta-lipoxygenase activity ;   12S-lipoxygenase activity ;   C-12 lipoxygenase activity ;   LTA4 synthase activity ;   arachidonate:oxygen 12-oxidoreductase activity ;   delta12-lipoxygenase activity
Broad Synonyms: leukotriene A4 synthase
Related Synonyms: 12-lipoxygenase activity
Xrefs: EC:1.13.11.31 ;   KEGG_REACTION:R01596 ;   MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN ;   RHEA:10428 ;   reactome:R-HSA-2161948 "Arachidonic acid is converted to 12-oxoETE by ALOX12" ;   reactome:R-HSA-2161950 "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B" ;   reactome:R-HSA-2161964 "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15" ;   reactome:R-HSA-9024983 "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA" ;   reactome:R-HSA-9025957 "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6" ;   reactome:R-HSA-9026006 "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3" ;   reactome:R-HSA-9026007 "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3"
Definition Sources: EC:1.13.11.31, RHEA:10428

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.