Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

Term:
GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity (GO:0004377)
Annotations: Rat: (1) Mouse: (1) Human: (1) Chinchilla: (0) Bonobo: (0) Dog: (1) Squirrel: (0) Pig: (1)
Parent Terms Term With Siblings Child Terms
dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity  
dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity  
GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity  
GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity  
Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
glycolipid 6-alpha-mannosyltransferase activity 

Synonyms
Exact Synonyms: GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity ;   GDP-mannose-oligosaccharide-lipid mannosyltransferase activity ;   GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity ;   glycolipid 2-alpha-mannosyltransferase activity ;   guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity ;   oligosaccharide-lipid mannosyltransferase activity
Xrefs: EC:2.4.1.131 ;   MetaCyc:2.4.1.131-RXN ;   RHEA:29523
Definition Sources: EC:2.4.1.131

paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.