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Term:
phospholipase A2 activity (GO:0004623)
Annotations: Rat: (31) Mouse: (31) Human: (36) Chinchilla: (29) Bonobo: (32) Dog: (25) Squirrel: (2) Pig: (25)
Parent Terms Term With Siblings Child Terms
1,2-diacylglycerol acylhydrolase activity 
1,3-diacylglycerol acylhydrolase activity 
1,4-lactonase activity 
1-16:0-2-18:2-phosphatidylcholine sn-1 acylhydrolase activity 
1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity  
1-acyl-2-lysophosphatidylserine acylhydrolase activity  
1-alkyl-2-acetylglycerophosphocholine esterase activity  
1-oxa-2-oxocycloheptane lactonase activity 
11-cis-retinyl-palmitate hydrolase activity 
2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase activity 
2-pyrone-4,6-dicarboxylate lactonase activity 
3,4-dihydrocoumarin hydrolase activity  
3-oxoadipate enol-lactonase activity 
4-methyloxaloacetate esterase activity 
4-O-methyl-glucuronoyl methylesterase activity 
4-pyridoxolactonase activity 
4-sulfomuconolactone hydrolase activity 
5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity 
6-acetylglucose deacetylase activity 
6-phosphogluconolactonase activity  
acetoxybutynylbithiophene deacetylase activity 
acetylajmaline esterase activity 
acetylalkylglycerol acetylhydrolase activity 
acetylsalicylate deacetylase activity 
acetylxylan esterase activity 
aclacinomycin A methylesterase activity 
aclacinomycin T methylesterase activity 
actinomycin lactonase activity 
acylcarnitine hydrolase activity  
acylglycerol lipase activity  
acyloxyacyl hydrolase activity  
all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity  
all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity  
all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity 
alpha-amino-acid esterase activity  
aminoacyl-tRNA editing activity +   
aminoacyl-tRNA hydrolase activity  
arylesterase activity  
bis(2-ethylhexyl)phthalate esterase activity 
brefeldin A esterase activity 
butyrolactone hydrolase activity 
carboxymethylenebutenolidase activity 
cardiolipin hydrolase activity  
cephalosporin-C deacetylase activity 
cetraxate benzylesterase activity 
chitooligosaccharide deacetylase activity 
chlorogenate hydrolase activity 
chlorophyllase activity 
cholinesterase activity +   
cutinase activity 
D-arabinonolactonase activity 
deoxylimonate A-ring-lactonase activity 
dihydrocoumarin hydrolase activity 
diphthine methylesterase activity  
endosulfan lactone lactonase activity 
epsilon-rhodomycinone methylesterase activity 
fatty-acyl-ethyl-ester synthase activity  
feruloyl esterase activity 
fusarinine-C ornithinesterase activity 
galactolipase activity  
gluconolactonase activity  
heparan sulfate N-deacetylase activity 
hormone-sensitive lipase activity  
hydroxybutyrate-dimer hydrolase activity 
juvenile-hormone esterase activity 
L-arabinonolactonase activity 
L-ascorbate 6-phosphate lactonase activity 
L-rhamnono-1,4-lactonase activity 
lactonohydrolase activity +   
limonin-D-ring-lactonase activity 
lysophospholipase activity  
methyl indole-3-acetate esterase activity  
methyl jasmonate esterase activity 
methyl salicylate esterase activity 
methylumbelliferyl-acetate deacetylase activity  
mycophenolic acid acyl-glucuronide esterase activity  
N-acetylgalactosaminoglycan deacetylase activity 
N-acylphosphatidylethanolamine-specific phospholipase D activity  
orsellinate-depside hydrolase activity 
palmitoleyl hydrolase activity  
pectin acetylesterase activity 
pectinesterase activity 
pheophoridase activity 
pheophytinase activity 
pheophytinase b activity 
phorbol-diester hydrolase activity 
phosphatidyl phospholipase B activity 
phosphatidylinositol deacylase activity  
phosphatidylserine 1-acylhydrolase activity  
phospholipase A1 activity  
phospholipase A2 activity +   
Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)  
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)  
phospholipase C activity +   
phospholipase D activity +   
pimelyl-[acyl-carrier protein] methyl ester esterase activity 
poly(3-hydroxybutyrate) depolymerase activity 
poly(3-hydroxyoctanoate) depolymerase activity 
polyneuridine-aldehyde esterase activity 
protein methylesterase activity +   
retinyl-palmitate esterase activity  
Ser(Gly)-tRNA(Ala) hydrolase activity 
Ser-tRNA(Thr) hydrolase activity 
short-chain carboxylesterase activity +   
sinapine esterase activity 
sphingomyelin phosphodiesterase activity +   
sphingomyelin phosphodiesterase D activity  
steroid-lactonase activity 
sterol esterase activity  
sulfolactone hydrolase activity 
tannase activity 
trans-permethrin hydrolase activity  
triacetate-lactonase activity 
triglyceride lipase activity +   
tropinesterase activity 
uronolactonase activity 
vinylacetate caboxylester hydrolase activity 
wax-ester hydrolase activity 
xylono-1,4-lactonase activity 

Synonyms
Exact Synonyms: lecithinase A activity ;   phosphatidolipase activity ;   phosphatidylcholine 2-acylhydrolase activity
Narrow Synonyms: cytosolic phospholipase A2 activity ;   secreted phospholipase A2 activity
Related Synonyms: phosphatidase activity ;   phospholipase A
Xrefs: EC:3.1.1.4 ;   MetaCyc:PHOSPHOLIPASE-A2-RXN ;   RHEA:15801 ;   reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)" ;   reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]" ;   reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A" ;   reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)" ;   reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)" ;   reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]" ;   reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A" ;   reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)" ;   reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]" ;   reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]" ;   reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]" ;   reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]" ;   reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]" ;   reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]" ;   reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]" ;   reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]" ;   reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A" ;   reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]" ;   reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]" ;   reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]" ;   reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]" ;   reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1" ;   reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]" ;   reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]" ;   reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane"
Definition Sources: EC:3.1.1.4

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.