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Term:
phosphoprotein phosphatase activity (GO:0004721)
Annotations: Rat: (172) Mouse: (170) Human: (182) Chinchilla: (167) Bonobo: (169) Dog: (143) Squirrel: (6) Pig: (151)
Parent Terms Term With Siblings Child Terms
10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity  
2-carboxy-D-arabinitol-1-phosphatase activity 
2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity  
2-phosphosulfolactate phosphatase activity 
3',5'-nucleotide bisphosphate phosphatase activity  
3-deoxy-manno-octulosonate-8-phosphatase activity 
3-phosphoglycerate phosphatase activity 
3-phytase activity 
4-phytase activity 
5'-deoxynucleotidase activity  
5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity 
5-phytase activity 
6-phosophogluco-3-phosphogluco-starch phosphatase activity 
[acyl-carrier-protein] phosphodiesterase activity 
[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase 
[protein-PII] uridylyltransferase activity 
acid phosphatase activity +   
acireductone synthase activity  
ADP-phosphoglycerate phosphatase activity 
alkaline phosphatase activity  
alkylacetylglycerophosphatase activity 
alpha-1,4-glucan-protein synthase (ADP-forming) activity 
alpha-ribazole phosphatase activity 
aryldialkylphosphatase activity  
biotin-protein ligase activity +   
bisphosphoglycerate phosphatase activity +   
caldesmon-phosphatase activity 
carbohydrate phosphatase activity +   
catalytic activity, acting on a glycoprotein +   
D,D-heptose 1,7-bisphosphate phosphatase activity 
deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity 
deoxynucleotide 3'-phosphatase activity 
dihydrolipoyllysine-residue acetyltransferase activity  
dihydrolipoyllysine-residue succinyltransferase activity  
dihydrosphingosine-1-phosphate phosphatase activity 
dolichyl-phosphatase activity 
ecdysone-phosphate phosphatase activity 
ecdysteroid-phosphate phosphatase activity 
FMN hydrolase activity 
FMN phosphatase activity 
fructose-1-phosphatase activity 
glucosylglycerol 3-phosphatase activity 
glycerol-1-phosphatase activity  
glycerol-2-phosphatase activity 
glycerol-3-phosphatase activity  
GPI-anchor transamidase activity  
guanidinodeoxy-scyllo-inositol-4-phosphatase activity 
histidinol-phosphatase activity 
histone demethylase activity +   
inositol phosphate phosphatase activity +   
L-threonine O-3-phosphate phosphatase activity 
lipid phosphatase activity +   
lipoate-protein ligase activity 
lysophosphatidic acid phosphatase activity  
mannitol-1-phosphatase activity 
mannosyl-3-phosphoglycerate phosphatase activity 
methylphosphothioglycerate phosphatase activity 
microtubule plus end polymerase  
microtubule-severing ATPase activity  
N-acylneuraminate-9-phosphatase activity  
NADP phosphatase activity  
NADPH phosphatase activity  
NMN phosphatase activity 
nucleotidase activity +   
nucleotide phosphatase activity, acting on free nucleotides +   
palmitoyl-(protein) hydrolase activity  
peptidase activity +   
peptide alpha-N-propionyltransferase activity 
peptide-aspartate beta-dioxygenase activity  
peptide-O-fucosyltransferase activity  
peptide-tryptophan 2,3-dioxygenase activity 
peptidyl-arginine 3-dioxygenase activity 
peptidyl-asparagine 3-dioxygenase activity  
peptidyl-aspartic acid 3-dioxygenase activity  
peptidyl-cysteine S-nitrosylase activity  
peptidyl-histidine dioxygenase activity  
peptidyl-lysine 3-dioxygenase activity 
peptidyl-lysine 4-dioxygenase activity 
peptidyl-lysine 5-dioxygenase activity +   
peptidyl-lysine N6-palmitoyltransferase activity 
peptidyl-proline dioxygenase activity +   
peptidyl-prolyl cis-trans isomerase activity  
peptidylamidoglycolate lyase activity  
phosphatidate phosphatase activity  
phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity 
phosphatidylglycerophosphatase activity  
phosphatidylinositol phosphate phosphatase activity +   
phosphatidylinositol-5-phosphate 5-phosphatase activity 
phosphocholine phosphatase activity  
phosphoenolpyruvate phosphatase activity 
phosphoethanolamine phosphatase activity  
phosphoglycerate phosphatase activity 
phosphoglycolate phosphatase activity  
phosphoprotein phosphatase activity +   
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
phosphoserine phosphatase activity +   
polynucleotide phosphatase activity +   
polypeptide N-acetylgalactosaminyltransferase activity  
procollagen galactosyltransferase activity  
procollagen glucosyltransferase activity  
protein adenylylhydrolase activity  
protein ADP-ribosylase activity  
protein deacetylase activity +   
protein deglycase activity  
protein disulfide isomerase activity  
protein kinase activity +   
protein methylesterase activity +   
protein methylthiotransferase activity 
protein methyltransferase activity +   
protein N-acetylglucosaminyltransferase activity  
protein prenyltransferase activity +   
protein xylosyltransferase activity  
protein-cysteine S-acyltransferase activity +   
protein-fructosamine 3-kinase activity  
protein-glucosylgalactosylhydroxylysine glucosidase activity  
protein-glutamic acid ligase activity +   
protein-glycine ligase activity +   
protein-lysine 6-oxidase activity  
protein-ribulosamine 3-kinase activity  
protein-tyrosine sulfotransferase activity  
pseudouridine 5'-phosphatase activity  
pyridoxal phosphatase activity  
ribitol-5-phosphatase activity 
sedoheptulose-bisphosphatase activity 
Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity 
sorbitol-6-phosphatase activity 
streptomycin-6-phosphatase activity 
thymidylate 5'-phosphatase activity 
transferase activity, transferring amino-acyl groups +   
tubulin-tyrosine ligase activity  
ubiquitin-like protein transferase activity +   
ubiquitinyl hydrolase activity +   

Synonyms
Exact Synonyms: phosphoprotein phosphohydrolase activity ;   protein phosphatase activity
Narrow Synonyms: protein phosphatase-1 activity ;   protein phosphatase-2A activity ;   protein phosphatase-2B activity ;   protein phosphatase-2C activity
Xrefs: EC:3.1.3.16 ;   MetaCyc:3.1.3.16-RXN ;   reactome:R-HSA-112383 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein" ;   reactome:R-HSA-113503 "PP2A mediated localization of RB1 protein in chromatin" ;   reactome:R-HSA-1363274 "Dephosphorylation of p107 (RBL1) by PP2A" ;   reactome:R-HSA-1363276 "Dephosphorylation of p130 (RBL2) by PP2A" ;   reactome:R-HSA-167072 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein" ;   reactome:R-HSA-170153 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases" ;   reactome:R-HSA-170158 "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes" ;   reactome:R-HSA-170161 "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B" ;   reactome:R-HSA-174110 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2" ;   reactome:R-HSA-174124 "Dephosphorylation of phospho-Cdh1" ;   reactome:R-HSA-178178 "PP1 dephosphorylates TGFBR1" ;   reactome:R-HSA-2529015 "Dephosphorylation of CK2-modified condensin I" ;   reactome:R-HSA-69199 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A"
Definition Sources: EC:3.1.3.16, ISBN:0198547684

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.