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protein serine/threonine phosphatase activity (GO:0004722)
Annotations: Rat: (59) Mouse: (64) Human: (76) Chinchilla: (64) Bonobo: (67) Dog: (52) Squirrel: (1) Pig: (52)
Parent Terms Term With Siblings Child Terms
[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity 
[acetyl-CoA carboxylase]-phosphatase activity 
[glycogen-synthase-D] phosphatase activity 
[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity 
[isocitrate dehydrogenase (NADP+)] phosphatase activity 
[phosphorylase] phosphatase activity  
[pyruvate dehydrogenase (lipoamide)] phosphatase activity  
[pyruvate kinase]-phosphatase activity 
MAP kinase phosphatase activity +   
myosin-light-chain-phosphatase activity  
protein arginine phosphatase activity 
protein histidine phosphatase activity  
protein serine/threonine phosphatase activity +   
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
protein tyrosine phosphatase activity +   
protein tyrosine/serine/threonine phosphatase activity +   
protein tyrosine/threonine phosphatase activity  
transmembrane receptor protein phosphatase activity +   

Exact Synonyms: serine/threonine specific protein phosphatase activity
Narrow Synonyms: 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase ;   Aspergillus awamori acid protein phosphatase ;   BCKDH phosphatase ;   HMG-CoA reductase phosphatase ;   branched-chain alpha-keto acid dehydrogenase phosphatase ;   calcineurin ;   casein phosphatase ;   phosphatase 2A ;   phosphatase 2B ;   phosphatase C-II ;   phosphatase H-II ;   phosphatase I ;   phosphatase IB ;   phosphatase II ;   phosphatase III ;   phosphatase IV ;   phosphatase SP ;   phosphopyruvate dehydrogenase phosphatase ;   phosphospectrin phosphatase ;   polycation modulated (PCM-) phosphatase ;   protein D phosphatase ;   protein phosphatase X ;   protein phosphatase type 1 activity ;   protein phosphatase type 1, intrinsic catalyst activity ;   protein phosphatase type 2A activity ;   protein phosphatase type 2A, intrinsic catalyst activity ;   protein phosphatase type 2B activity ;   protein phosphatase type 2B, intrinsic catalyst activity ;   protein phosphatase type 2C activity ;   protein phosphatase type 4 activity ;   protein phosphatase type 4, intrinsic catalyst activity
Alternate IDs: GO:0000158 ;   GO:0000163 ;   GO:0008598 ;   GO:0008600 ;   GO:0015071 ;   GO:0030357 ;   GO:0030358 ;   GO:0030360 ;   GO:0030361
Xrefs: reactome:R-HSA-1295632 "PPA2A dephosphorylates SPRY2" ;   reactome:R-HSA-163568 "phosphorylated perilipin + H2O -> perilipin + orthophosphate" ;   reactome:R-HSA-1638821 "PP2A-B56 dephosphorylates centromeric cohesin" ;   reactome:R-HSA-199425 "PHLPP dephosphorylates S473 in AKT" ;   reactome:R-HSA-199959 "ERKs are inactivated by protein phosphatase 2A" ;   reactome:R-HSA-201787 "PPP3 complex dephosphorylates DARPP-32 on Thr34" ;   reactome:R-HSA-201790 "DARPP-32 is dephosphorylated on Thr75 by PP2A" ;   reactome:R-HSA-209055 "PPM1A dephosphorylates nuclear SMAD2/3" ;   reactome:R-HSA-2187401 "MTMR4 dephosphorylates SMAD2/3" ;   reactome:R-HSA-2995388 "PP2A dephosphorylates BANF1" ;   reactome:R-HSA-3002811 "Myosin phosphatase dephosphorylates PLK1" ;   reactome:R-HSA-3601585 "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex" ;   reactome:R-HSA-380949 "AMPK is dephosphorylated" ;   reactome:R-HSA-4088141 "PP2A-PPP2R2A dephosphorylates FOXM1" ;   reactome:R-HSA-429730 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate" ;   reactome:R-HSA-4419948 "CTDNEP1:CNEP1R1 dephosphorylates LPIN" ;   reactome:R-HSA-5672957 "PP2A dephosphorylates KSR1" ;   reactome:R-HSA-5672961 "PP2A dephosphorylates inactive RAFs" ;   reactome:R-HSA-5675431 "PP2A dephosphorylates RAF1" ;   reactome:R-HSA-5675433 "PP5 dephosphorylates RAF1 S338" ;   reactome:R-HSA-5679206 "MTMR14, MTMR3 dephosphorylate PI3P" ;   reactome:R-HSA-5683405 "PPP5C dephosphorylates TP53BP1" ;   reactome:R-HSA-5687758 "PPP4C:PPP4R2 dephosphorylates RPA2" ;   reactome:R-HSA-5692754 "CDC14A,B dephosphorylate p-3S,T MAPK6" ;   reactome:R-HSA-5693153 "PPM1K dephosphorylates p-BCKDH" ;   reactome:R-HSA-5694421 "PP6 dephosphorylates SEC24" ;   reactome:R-HSA-6792863 "PP2A-PP2R5C dephosphorylates MDM2" ;   reactome:R-HSA-6811504 "AKT1 dephosphorylation by PP2A-B56-beta,gamma" ;   reactome:R-HSA-6814559 "Pre-snRNA is elongated and capped with 7-methylguanosine" ;   reactome:R-HSA-74948 "PP2A dephosphorylates p-RHO to RHO" ;   reactome:R-HSA-8948139 "p-S13-FUNDC1 is dephosphorylated by PGAM5" ;   reactome:R-HSA-9619430 "PPM1E dephosphorylates CAMK4" ;   reactome:R-HSA-9619449 "PPM1F dephosphorylates p-T286-CaMKII" ;   reactome:R-HSA-9619467 "PPM1F dephosphorylates CAMK1"
Definition Sources: GOC:bf

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.