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non-membrane spanning protein tyrosine phosphatase activity (GO:0004726)
Annotations: Rat: (6) Mouse: (6) Human: (8) Chinchilla: (8) Bonobo: (8) Dog: (4) Squirrel: (0) Pig: (5)
Parent Terms Term With Siblings Child Terms
MAP kinase tyrosine phosphatase activity 
non-membrane spanning protein tyrosine phosphatase activity  
Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.
prenylated protein tyrosine phosphatase activity  
protein tyrosine phosphatase activity, metal-dependent 
protein tyrosine phosphatase activity, via thiol-phosphate intermediate 
transmembrane receptor protein tyrosine phosphatase activity  

Xrefs: reactome:R-HSA-177923 "Sustained activation of SRC kinase by SHP2" ;   reactome:R-HSA-177924 "Dephosphorylation of Gab1 by SHP2" ;   reactome:R-HSA-177926 "Dephosphorylation of PAG by SHP2" ;   reactome:R-HSA-177935 "SHP2 dephosphorylates Tyr 992 on EGFR"
Definition Sources: EC:

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.