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Ontology Browser

Term:
nucleotide-excision repair (GO:0006289)
Annotations: Rat: (62) Mouse: (58) Human: (117) Chinchilla: (43) Bonobo: (44) Dog: (56) Squirrel: (43) Pig: (54)
Parent Terms Term With Siblings Child Terms
DNA repair +     
base-excision repair +   
DNA dealkylation involved in DNA repair  
DNA ligation involved in DNA repair +   
DNA replication proofreading  
DNA synthesis involved in DNA repair +   
double-strand break repair +   
interstrand cross-link repair +   
mismatch repair +   
mitochondrial DNA repair  
negative regulation of DNA repair +   
non-photoreactive DNA repair 
non-recombinational repair +   
nucleotide phosphorylation involved in DNA repair 
nucleotide-excision repair +   
A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
positive regulation of DNA repair +   
postreplication repair +   
protein-DNA covalent cross-linking repair 
pyrimidine dimer repair +   
recombinational repair +   
regulation of DNA repair +   
single strand break repair +   
UV-damage excision repair +   
viral DNA repair +  

Synonyms
Exact Synonyms: NER ;   pyrimidine-dimer repair, DNA damage excision
Related Synonyms: intrastrand cross-link repair
Alternate IDs: GO:0045001
Definition Sources: PMID:10197977

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.