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Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
apoptotic process +   
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
autolysis 
autophagic cell death +   
cornification +   
ferroptosis +   
host programmed cell death induced by symbiont +   
mitochondrial outer membrane permeabilization involved in programmed cell death +   
negative regulation of programmed cell death +   
positive regulation of programmed cell death +   
programmed cell death in response to reactive oxygen species +   
programmed cell death involved in cell development +   
programmed necrotic cell death +   
pyroptosis  
regulation of programmed cell death +   

Synonyms
Exact Synonyms: apoptotic cell death ;   apoptotic programmed cell death ;   programmed cell death by apoptosis
Narrow Synonyms: activation of apoptosis ;   apoptosis ;   apoptosis signaling ;   apoptotic program ;   type I programmed cell death
Broad Synonyms: cell suicide ;   cellular suicide
Related Synonyms: apoptosis activator activity ;   caspase-dependent programmed cell death ;   commitment to apoptosis ;   induction of apoptosis ;   induction of apoptosis by p53 ;   signaling (initiator) caspase activity
Alternate IDs: GO:0006917 ;   GO:0008632
Xrefs: MIPS_funcat:40.10.02 ;   Wikipedia:Apoptosis
Never In Taxon: NCBITaxon:33090 ! Viridiplantae
Definition Sources: GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.