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Ontology Browser

Term:
G protein-coupled receptor signaling pathway (GO:0007186)
Annotations: Rat: (2509) Mouse: (1995) Human: (1433) Chinchilla: (449) Bonobo: (469) Dog: (1370) Squirrel: (449) Pig: (1840)
Parent Terms Term With Siblings Child Terms
apoptotic signaling pathway +   
bile acid signaling pathway +   
calmodulin dependent kinase signaling pathway +   
carbohydrate mediated signaling +   
cell surface receptor signaling pathway +   
chloroplast-nucleus signaling pathway 
dopamine receptor signaling pathway +   
endoplasmic reticulum unfolded protein response +   
ER-nucleus signaling pathway +   
extracellular ATP signaling 
G protein-coupled receptor signaling pathway +   
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
granzyme-mediated programmed cell death signaling pathway +   
hormone-mediated signaling pathway +   
hydrogen peroxide mediated signaling pathway +  
hypoxia-inducible factor-1alpha signaling pathway +   
immune response-regulating signaling pathway +   
intracellular receptor signaling pathway +   
intracellular signal transduction +   
ligand-gated ion channel signaling pathway +  
lipoprotein particle mediated signaling +   
mitochondria-nucleus signaling pathway  
necroptotic signaling pathway  
negative regulation of signal transduction +   
neuronal signal transduction +   
osmosensory signaling pathway +   
pattern recognition receptor signaling pathway +   
peptidoglycan recognition protein signaling pathway +  
phototransduction +   
positive regulation of signal transduction +   
postsynaptic signal transduction +   
presynaptic signal transduction +   
red or far-red light signaling pathway +   
regulation of blood pressure by chemoreceptor signaling pathway 
regulation of floral organ abscission by signal transduction +  
regulation of signal transduction +   
salicylic acid mediated signaling pathway +  
serotonin receptor signaling pathway +   
signal transduction by conformational transition 
signal transduction by protein phosphorylation +   
signal transduction in absence of ligand +   
signal transduction involved in cellular response to ammonium ion 
signal transduction involved in filamentous growth 
signal transduction involved in morphogenesis checkpoint 
signal transduction involved in positive regulation of conjugation with cellular fusion +  
signal transduction involved in regulation of gene expression  
SMAD protein signal transduction +   
sphingolipid mediated signaling pathway +   

Synonyms
Exact Synonyms: G protein coupled receptor protein signaling pathway ;   G protein coupled receptor protein signalling pathway ;   G-protein coupled receptor protein signal transduction ;   G-protein coupled receptor signalling pathway ;   GPCR signaling pathway ;   GPCR signalling pathway
Narrow Synonyms: G-protein coupled receptor signaling pathway via GPCR dimer ;   dimeric G-protein coupled receptor signaling pathway ;   dimeric G-protein coupled receptor signalling pathway
Alternate IDs: GO:0038042
Definition Sources: GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.