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Ontology Browser

Term:
G protein-coupled receptor signaling pathway (GO:0007186)
Annotations: Rat: (2395) Mouse: (1929) Human: (1386) Chinchilla: (889) Bonobo: (1114) Dog: (1043) Squirrel: (37) Pig: (1844)
Parent Terms Term With Siblings Child Terms
apoptotic signaling pathway +   
bile acid signaling pathway +   
calmodulin dependent kinase signaling pathway +   
carbohydrate mediated signaling +   
cell surface receptor signaling pathway +   
chloroplast-nucleus signaling pathway 
defense response signaling pathway, resistance gene-dependent 
defense response signaling pathway, resistance gene-independent 
endoplasmic reticulum unfolded protein response +   
ER-nucleus signaling pathway +   
extracellular ATP signaling 
G protein-coupled receptor signaling pathway +   
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
hormone-mediated signaling pathway +   
hydrogen peroxide mediated signaling pathway +  
hypoxia-inducible factor-1alpha signaling pathway +   
immune response-regulating signaling pathway +   
intracellular receptor signaling pathway +   
intracellular signal transduction +   
ligand-gated ion channel signaling pathway +  
lipoprotein particle mediated signaling +   
mitochondria-nucleus signaling pathway  
necroptotic signaling pathway  
negative regulation of signal transduction +   
neuronal signal transduction +   
osmosensory signaling pathway +   
peptidoglycan recognition protein signaling pathway +  
phototransduction +   
positive regulation of signal transduction +   
postsynaptic signal transduction +   
presynaptic signal transduction +   
red or far-red light signaling pathway +   
regulation of blood pressure by chemoreceptor signaling pathway 
regulation of floral organ abscission by signal transduction +  
regulation of signal transduction +   
salicylic acid mediated signaling pathway +  
signal transduction by conformational transition 
signal transduction by protein phosphorylation +   
signal transduction in absence of ligand +   
signal transduction involved in cellular response to ammonium ion +   
signal transduction involved in filamentous growth 
signal transduction involved in morphogenesis checkpoint 
signal transduction involved in positive regulation of conjugation with cellular fusion +  
signal transduction involved in regulation of aerobic respiration  
signal transduction involved in regulation of gene expression  
SMAD protein signal transduction +   
sphingolipid mediated signaling pathway +   

Synonyms
Exact Synonyms: G protein coupled receptor protein signaling pathway ;   G protein coupled receptor protein signalling pathway ;   G-protein coupled receptor protein signal transduction ;   G-protein coupled receptor signalling pathway ;   GPCR signaling pathway ;   GPCR signalling pathway
Narrow Synonyms: G-protein coupled receptor signaling pathway via GPCR dimer ;   dimeric G-protein coupled receptor signaling pathway ;   dimeric G-protein coupled receptor signalling pathway
Alternate IDs: GO:0038042
Xrefs: MIPS_funcat:30.01.05.05 ;   MIPS_funcat:30.05.02.24
Definition Sources: GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.