Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

patched ligand maturation (GO:0007225)
Annotations: Rat: (1) Mouse: (1) Human: (1) Chinchilla: (1) Bonobo: (1) Dog: (1) Squirrel: (0) Pig: (1)
Parent Terms Term With Siblings Child Terms
CAAX-box protein maturation +   
epidermal growth factor receptor ligand maturation +  
N-terminal protein amino acid acetylation +   
negative regulation of protein maturation +   
patched ligand maturation  
The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups.
peptide pheromone maturation +  
peptidyl-lysine modification to peptidyl-hypusine  
positive regulation of protein maturation +   
positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning  
protein initiator methionine removal involved in protein maturation 
protein lipoylation  
protein maturation by copper ion transfer  
protein maturation by iron-sulfur cluster transfer +   
protein maturation by nickel ion transfer 
protein maturation by protein folding  
protein processing +   
regulation of protein maturation +   

Exact Synonyms: hh protein processing
Narrow Synonyms: Hedgehog protein processing
Related Synonyms: patched ligand processing
Definition Sources: PMID:15057936

paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.