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Ontology Browser

Term:
signal transduction downstream of smoothened (GO:0007227)
Annotations: Rat: (4) Mouse: (4) Human: (4) Chinchilla: (4) Bonobo: (4) Dog: (3) Squirrel: (4) Pig: (4)
Parent Terms Term With Siblings Child Terms
ciliary receptor clustering involved in smoothened signaling pathway  
cytoplasmic pattern recognition receptor signaling pathway +   
endosomal signal transduction 
hippo signaling +   
I-kappaB kinase/NF-kappaB signaling +   
inositol lipid-mediated signaling +   
intracellular signal transduction involved in positive regulation of cell growth 
intrinsic apoptotic signaling pathway +   
MAPK cascade +   
mesenchymal smoothened signaling pathway involved in prostate gland development  
negative regulation of intracellular signal transduction +   
negative regulation of smoothened signaling pathway +   
NIK/NF-kappaB signaling +   
phosphorelay signal transduction system +   
PKR-mediated signaling 
positive regulation of intracellular signal transduction +   
positive regulation of smoothened signaling pathway +   
protein kinase A signaling +   
protein kinase B signaling +   
protein kinase C signaling +   
protein kinase D signaling +   
RAM/MOR signaling pathway 
regulation of intracellular signal transduction +   
regulation of smoothened signaling pathway +   
second-messenger-mediated signaling +   
signal transduction by p53 class mediator +   
signal transduction downstream of smoothened +   
The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.
signal transduction in response to DNA damage +   
signal transduction involved in cell cycle checkpoint +   
signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle 
small GTPase mediated signal transduction +   
smoothened signaling pathway involved in dorsal/ventral neural tube patterning +   
smoothened signaling pathway involved in growth plate cartilage chondrocyte development 
smoothened signaling pathway involved in lung development  
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation  
smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation  
smoothened signaling pathway involved in ventral spinal cord patterning +   
stress-activated protein kinase signaling cascade +   
TOR signaling +   
TRAF-mediated signal transduction  

Synonyms
Definition Sources: PMID:15057936

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.