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Ontology Browser

Term:
I-kappaB kinase/NF-kappaB signaling (GO:0007249)
Annotations: Rat: (273) Mouse: (275) Human: (298) Chinchilla: (232) Bonobo: (247) Dog: (267) Squirrel: (230) Pig: (268)
Parent Terms Term With Siblings Child Terms
cytoplasmic pattern recognition receptor signaling pathway +   
endosomal signal transduction 
hippo signaling +   
I-kappaB kinase/NF-kappaB signaling +   
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
inositol lipid-mediated signaling +   
intracellular signal transduction involved in positive regulation of cell growth 
intrinsic apoptotic signaling pathway +   
MAPK cascade +   
negative regulation of intracellular signal transduction +   
NIK/NF-kappaB signaling +   
phosphorelay signal transduction system +   
PKR-mediated signaling 
positive regulation of intracellular signal transduction +   
protein kinase A signaling +   
protein kinase B signaling +   
protein kinase C signaling +   
protein kinase D signaling +   
RAM/MOR signaling pathway 
regulation of intracellular signal transduction +   
second-messenger-mediated signaling +   
signal transduction by p53 class mediator +   
signal transduction downstream of smoothened +   
signal transduction in response to DNA damage +   
signal transduction involved in cell cycle checkpoint +   
signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle 
small GTPase mediated signal transduction +   
stress-activated protein kinase signaling cascade +   
TOR signaling +   
TRAF-mediated signal transduction  

Synonyms
Exact Synonyms: I-kappaB kinase/NF-kappaB signal transduction ;   NF-kappaB cascade ;   canonical NF-kappaB signaling cascade
Related Synonyms: I-kappaB kinase/NF-kappaB cascade ;   activation of the inhibitor of kappa kinase ;   p50-dependent NF-kappaB signaling
Definition Sources: GOC:bf, GOC:jl, PMID:12773372, Reactome:R-HSA-209560

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.