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Term:
IkappaB kinase complex (GO:0008385)
Annotations: Rat: (7) Mouse: (8) Human: (9) Chinchilla: (7) Bonobo: (9) Dog: (7) Squirrel: (9) Pig: (8)
Parent Terms Term With Siblings Child Terms
3-isopropylmalate dehydratase complex 
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex  
6-phosphofructokinase complex  
activin receptor complex  
alkanesulfonate monooxygenase complex 
apoptosome  
Atg1/ULK1 kinase complex  
bacterial degradosome 
BLOC complex +   
BORC complex  
carboxy-terminal domain protein kinase complex +   
chaperonin ATPase complex +  
chaperonin-containing T-complex  
CIA complex  
cyclin-dependent protein kinase holoenzyme complex +   
cytoplasmic RNA cap binding complex 
cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex 
cytosolic aryl hydrocarbon receptor complex  
cytosolic creatine kinase complex 
cytosolic DNA-directed RNA polymerase complex 
cytosolic electron transfer flavoprotein complex 
cytosolic oxoglutarate dehydrogenase complex 
cytosolic proteasome complex +   
cytosolic pyruvate dehydrogenase complex 
cytosolic ribosome +   
cytosolic tricarboxylic acid cycle enzyme complex +  
cytosolic tRNA wobble base thiouridylase complex  
DAPK1-calmodulin complex 
diamine N-acetyltransferase complex 
DNA-dependent protein kinase complex  
ER membrane insertion complex +   
fatty acid synthase complex 
fatty-acyl-CoA synthase complex 
FMN reductase complex 
FtsBL complex 
Gin4 complex 
GLI-SUFU complex 
guanylate cyclase complex, soluble  
H-NS complex 
H-NS-Hha complex 
hemoglobin complex  
IkappaB kinase complex  
A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
inflammasome complex +   
intramolecular phosphotransferase complex +  
Ire1 complex  
iron-sulfur cluster assembly complex +  
iron-sulfur cluster transfer complex 
L-cysteine desulfurase complex +   
Las1 complex  
mCRD-mediated mRNA stability complex 
ModE complex 
molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex 
PAR polarity complex 
phosphopyruvate hydratase complex  
phosphorylase kinase complex  
protein kinase 5 complex  
region of cytosol +   
ribonucleoside-diphosphate reductase complex  
ripoptosome  
SsuD-SsuE complex 
steroid hormone aporeceptor complex  
sulfurtransferase complex +  
taurine dioxygenase complex 
transforming growth factor beta ligand-receptor complex 
TSC1-TSC2 complex  
Yae1-Lto1 complex 

Synonyms
Exact Synonyms: IKK complex ;   heterotrimeric IKK complex ;   trimeric IKK complex
Definition Sources: GOC:bf, GOC:ma, PMID:12055104, PMID:20300203

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.