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Term:
microtubule-severing ATPase activity (GO:0008568)
Annotations: Rat: (9) Mouse: (8) Human: (8) Chinchilla: (3) Bonobo: (3) Dog: (7) Squirrel: (3) Pig: (7)
Parent Terms Term With Siblings Child Terms
[acyl-carrier-protein] phosphodiesterase activity 
[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase 
[protein-PII] uridylyltransferase activity 
actin-dependent ATPase activity  
alpha-1,4-glucan-protein synthase (ADP-forming) activity 
ATP-dependent microtubule motor activity +   
ATP-dependent peptidase activity  
biotin-protein ligase activity +   
calcium-dependent ATPase activity  
catalytic activity, acting on a glycoprotein +   
clathrin-uncoating ATPase activity  
deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity 
dihydrolipoyllysine-residue acetyltransferase activity  
dihydrolipoyllysine-residue succinyltransferase activity  
DNA clamp unloader activity  
DNA-dependent ATPase activity +   
helicase activity +   
lipoate-protein ligase activity  
microtubule plus end polymerase  
microtubule-severing ATPase activity  
Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP.
nucleosome-dependent ATPase activity  
palmitoyl-(protein) hydrolase activity  
peptidase activity +   
peptide alpha-N-propionyltransferase activity 
peptide-aspartate beta-dioxygenase activity  
peptide-O-fucosyltransferase activity  
peptide-tryptophan 2,3-dioxygenase activity 
peptidyl-arginine 3-dioxygenase activity 
peptidyl-asparagine 3-dioxygenase activity  
peptidyl-aspartic acid 3-dioxygenase activity  
peptidyl-cysteine S-nitrosylase activity  
peptidyl-histidine dioxygenase activity  
peptidyl-lysine 3-dioxygenase activity 
peptidyl-lysine 4-dioxygenase activity 
peptidyl-lysine 5-dioxygenase activity +   
peptidyl-lysine N6-palmitoyltransferase activity 
peptidyl-proline dioxygenase activity +   
peptidyl-prolyl cis-trans isomerase activity  
peptidylamidoglycolate lyase activity  
phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity 
phosphoprotein phosphatase activity +   
polypeptide N-acetylgalactosaminyltransferase activity  
procollagen galactosyltransferase activity  
procollagen glucosyltransferase activity  
proteasome-activating ATPase activity  
protein adenylylhydrolase activity  
protein ADP-ribosylase activity  
protein deacetylase activity +   
protein deglycase activity  
protein demethylase activity +   
protein disulfide isomerase activity  
protein kinase activity +   
protein methylesterase activity +   
protein methylthiotransferase activity 
protein methyltransferase activity +   
protein N-acetylglucosaminyltransferase activity  
protein O-GlcNAc transferase activity  
protein prenyltransferase activity +   
protein xylosyltransferase activity  
protein-cysteine S-acyltransferase activity +   
protein-DNA unloading ATPase activity 
protein-fructosamine 3-kinase activity  
protein-glucosylgalactosylhydroxylysine glucosidase activity  
protein-glutamic acid ligase activity +   
protein-glycine ligase activity +   
protein-lysine 6-oxidase activity  
protein-ribulosamine 3-kinase activity  
protein-tyrosine sulfotransferase activity  
RNA-dependent ATPase activity +   
Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity 
transferase activity, transferring amino-acyl groups +   
tubulin-dependent ATPase activity  
tubulin-tyrosine ligase activity  
ubiquitin-like protein transferase activity +   
ubiquitinyl hydrolase activity +   

Synonyms
Exact Synonyms: ATP phosphohydrolase (tubulin-dimerizing)
Narrow Synonyms: katanin activity
Xrefs: EC:5.6.1.1 ;   MetaCyc:3.6.4.3-RXN ;   Reactome:R-HSA-9668419 "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites"
Definition Sources: EC:5.6.1.1, PMID:10910766

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.