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Term:
peptidyl-lysine modification to peptidyl-hypusine (GO:0008612)
Annotations: Rat: (2) Mouse: (2) Human: (3) Chinchilla: (2) Bonobo: (2) Dog: (2) Squirrel: (0) Pig: (2)
Parent Terms Term With Siblings Child Terms
archaeosine-tRNA biosynthetic process 
atropine biosynthetic process 
bacterial-type EF-P lysine modification +  
C-terminal peptidyl-lysine amidation 
CAAX-box protein maturation +   
cellular biosynthetic process +   
collagen biosynthetic process +   
cuticle hydrocarbon biosynthetic process 
epidermal growth factor receptor ligand maturation +  
hormone biosynthetic process +   
hydrogen biosynthetic process +  
isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine  
isopeptide cross-linking via N6-glycyl-L-lysine  
N-terminal protein amino acid acetylation +   
negative regulation of biosynthetic process +   
negative regulation of protein maturation +   
nicotine biosynthetic process 
organic substance biosynthetic process +   
patched ligand maturation  
peptide cross-linking via 2-tetrahydropyridinyl-5-imidazolinone glycine 
peptide cross-linking via 5'-(N6-L-lysine)-L-topaquinone 
peptide cross-linking via L-lysine 5-imidazolinone glycine 
peptide cross-linking via L-lysine thiazolecarboxylic acid 
peptide cross-linking via L-lysinoalanine 
peptide cross-linking via N6-(L-isoaspartyl)-L-lysine +  
peptide pheromone maturation +  
peptidoglycan-protein cross-linking via N6-mureinyl-L-lysine 
peptidyl-allysine oxidation to 2-aminoadipic acid 
peptidyl-L-lysine methyl ester biosynthetic process from peptidyl-lysine 
peptidyl-lysine acetylation +   
peptidyl-lysine adenylylation +  
peptidyl-lysine biotinylation 
peptidyl-lysine carboxyethylation 
peptidyl-lysine carboxylation 
peptidyl-lysine deacetylation  
peptidyl-lysine deglycation  
peptidyl-lysine demalonylation  
peptidyl-lysine desuccinylation  
peptidyl-lysine formylation 
peptidyl-lysine guanylylation +  
peptidyl-lysine hydroxylation +   
peptidyl-lysine malonylation 
peptidyl-lysine methylation +   
peptidyl-lysine modification to peptidyl-hypusine  
The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine.
peptidyl-lysine modification to peptidyl-N6-pyruvic acid 2-iminyl-L-lysine 
peptidyl-lysine myristoylation 
peptidyl-lysine oxidation  
peptidyl-lysine palmitoylation 
peptidyl-lysine succinylation 
phlobaphene biosynthetic process 
poly-N-methyl-propylamination 
positive regulation of biosynthetic process +   
positive regulation of protein maturation +   
protein desumoylation +   
protein initiator methionine removal involved in protein maturation 
protein lipoylation  
protein maturation by copper ion transfer  
protein maturation by iron-sulfur cluster transfer +   
protein maturation by nickel ion transfer 
protein maturation by protein folding  
protein O-linked glycosylation via hydroxylysine 
protein processing +   
protein pupylation 
protein sumoylation +   
protein-chromophore linkage via peptidyl-N6-3-dehydroretinal-L-lysine 
protein-chromophore linkage via peptidyl-N6-retinal-L-lysine 
protein-heme P460 linkage via heme P460-bis-L-cysteine-L-lysine 
protein-lysine lysylation 
protein-N6-(L-lysyl)-L-lysine modification to protein-N6-(beta-lysyl)-L-lysine 
protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine  
reactive oxygen species biosynthetic process +   
regulation of biosynthetic process +   
regulation of protein maturation +   
secondary metabolite biosynthetic process +   
small molecule biosynthetic process +   
tartrate biosynthetic process 
tyrocidine biosynthetic process 

Synonyms
Exact Synonyms: hypusine anabolism ;   hypusine anabolism from peptidyl-lysine ;   hypusine biosynthesis ;   hypusine biosynthetic process ;   hypusine biosynthetic process from peptidyl-lysine ;   hypusine formation ;   hypusine formation from peptidyl-lysine ;   hypusine synthesis ;   hypusine synthesis from peptidyl-lysine ;   hypusinylation ;   protein hypusination
Alternate IDs: GO:0046515
Xrefs: RESID:AA0116
Definition Sources: GOC:ma, ISBN:0198547684, RESID:AA0116

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.