Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

Term:
negative regulation of signal transduction (GO:0009968)
Annotations: Rat: (1198) Mouse: (1178) Human: (1260) Chinchilla: (1195) Bonobo: (1213) Dog: (490) Squirrel: (21) Pig: (355)
Parent Terms Term With Siblings Child Terms
adaptation of signaling pathway +   
apoptotic signaling pathway +   
bile acid signaling pathway +   
calmodulin dependent kinase signaling pathway +   
carbohydrate mediated signaling +   
cell surface receptor signaling pathway +   
chloroplast-nucleus signaling pathway 
defense response signaling pathway, resistance gene-dependent 
defense response signaling pathway, resistance gene-independent 
endoplasmic reticulum unfolded protein response +   
ER-nucleus signaling pathway +   
extracellular ATP signaling 
extracellular regulation of signal transduction +   
G protein-coupled receptor signaling pathway +   
hormone-mediated signaling pathway +   
hydrogen peroxide mediated signaling pathway +  
hypoxia-inducible factor-1alpha signaling pathway +   
immune response-regulating signaling pathway +   
intracellular receptor signaling pathway +   
intracellular signal transduction +   
ligand-gated ion channel signaling pathway +  
lipoprotein particle mediated signaling +   
mitochondria-nucleus signaling pathway  
modulation of excitatory postsynaptic potential +   
modulation of inhibitory postsynaptic potential +   
necroptotic signaling pathway  
negative regulation of aggregation involved in sorocarp development 
negative regulation of atrial cardiac muscle cell action potential +  
negative regulation of AV node cell action potential +  
negative regulation of BMP secretion +  
negative regulation of c-di-GMP signaling 
negative regulation of cardiac conduction +  
negative regulation of cell communication by chemical coupling 
negative regulation of cell communication by electrical coupling +   
negative regulation of cellular response to alkaline pH +  
negative regulation of cellular response to amino acid starvation 
negative regulation of cellular response to growth factor stimulus +   
negative regulation of cellular response to heat  
negative regulation of cellular response to hypoxia +   
negative regulation of cellular response to insulin stimulus +   
negative regulation of cellular response to iron ion starvation 
negative regulation of cellular response to manganese ion 
negative regulation of cellular response to nitrogen starvation 
negative regulation of cellular response to oxidopamine 
negative regulation of cellular response to phosphate starvation 
negative regulation of cellular response to testosterone stimulus  
negative regulation of cellular response to thapsigargin  
negative regulation of cellular response to tunicamycin  
negative regulation of cellular response to very-low-density lipoprotein particle stimulus 
negative regulation of cellular response to X-ray 
negative regulation of cellular senescence  
negative regulation of defense response +   
negative regulation of detection of glucose  
negative regulation of establishment of competence for transformation 
negative regulation of fear response +   
negative regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus 
negative regulation of filamentous growth of a population of unicellular organisms in response to heat 
negative regulation of filamentous growth of a population of unicellular organisms in response to pH +  
negative regulation of hormone secretion +   
negative regulation of immune response +   
negative regulation of insulin secretion involved in cellular response to glucose stimulus  
negative regulation of long-day photoperiodism, flowering 
negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from RNA polymerase II promoter 
negative regulation of muscle adaptation +   
negative regulation of neuron projection regeneration +   
negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization  
negative regulation of peroxidase activity +   
negative regulation of photomorphogenesis 
negative regulation of protein activation cascade +   
negative regulation of receptor recycling  
negative regulation of response to acetate +  
negative regulation of response to alcohol +  
negative regulation of response to amylopectin 
negative regulation of response to benzene 
negative regulation of response to biotic stimulus +   
negative regulation of response to calcium ion 
negative regulation of response to cycloalkane 
negative regulation of response to cytokine stimulus +   
negative regulation of response to DNA damage stimulus +   
negative regulation of response to drug +   
negative regulation of response to endoplasmic reticulum stress +   
negative regulation of response to external stimulus +   
negative regulation of response to furfural 
negative regulation of response to gamma radiation +   
negative regulation of response to oxidative stress +   
negative regulation of response to pullulan 
negative regulation of response to salt stress +  
negative regulation of response to water deprivation 
negative regulation of response to wounding +   
negative regulation of retrograde trans-synaptic signaling by neuropeptide  
negative regulation of shade avoidance 
negative regulation of short-day photoperiodism, flowering 
negative regulation of signal transduction +   
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
negative regulation of stress response to copper ion 
negative regulation of synaptic transmission +   
negative regulation of toluene catabolic process 
negative regulation of transmission of nerve impulse +   
negative regulation of trichome patterning 
negative regulation of vernalization response 
negative regulation of Wnt protein secretion  
negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane 
neuronal signal transduction +   
osmosensory signaling pathway +   
peptidoglycan recognition protein signaling pathway +  
phototransduction +   
positive regulation of signal transduction +   
postsynaptic signal transduction +   
presynaptic signal transduction +   
red or far-red light signaling pathway +   
regulation of abscisic acid-activated signaling pathway +   
regulation of anti-Mullerian hormone signaling pathway +   
regulation of antigen receptor-mediated signaling pathway +   
regulation of apolipoprotein A-I-mediated signaling pathway +  
regulation of apoptotic signaling pathway +   
regulation of auxin mediated signaling pathway +  
regulation of blood pressure by chemoreceptor signaling pathway 
regulation of brain-derived neurotrophic factor receptor signaling pathway +   
regulation of brassinosteroid mediated signaling pathway +  
regulation of CD40 signaling pathway +   
regulation of cytokine-mediated signaling pathway +   
regulation of cytokinin-activated signaling pathway +  
regulation of dopamine receptor signaling pathway +   
regulation of endoplasmic reticulum unfolded protein response +   
regulation of ephrin receptor signaling pathway +   
regulation of ERBB signaling pathway +   
regulation of Fas signaling pathway +   
regulation of Fc receptor mediated stimulatory signaling pathway +   
regulation of fibroblast growth factor receptor signaling pathway +   
regulation of floral organ abscission by signal transduction +  
regulation of G protein-coupled receptor signaling pathway +   
regulation of gibberellic acid mediated signaling pathway +  
regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +   
regulation of glucocorticoid mediated signaling pathway +   
regulation of glucose mediated signaling pathway +   
regulation of glutamate receptor signaling pathway +   
regulation of growth hormone receptor signaling pathway +   
regulation of hepatocyte growth factor receptor signaling pathway +   
regulation of hypoxia-inducible factor-1alpha signaling pathway +   
regulation of insulin receptor signaling pathway +   
regulation of insulin-like growth factor receptor signaling pathway +   
regulation of integrin-mediated signaling pathway +   
regulation of intracellular signal transduction +   
regulation of intracellular steroid hormone receptor signaling pathway +   
regulation of jasmonic acid mediated signaling pathway 
regulation of lipopolysaccharide-mediated signaling pathway +   
regulation of netrin-activated signaling pathway +   
regulation of neuronal signal transduction +   
regulation of neurotrophin TRK receptor signaling pathway +   
regulation of Notch signaling pathway +   
regulation of osmosensory signaling pathway +  
regulation of peptidoglycan recognition protein signaling pathway +  
regulation of peroxisome proliferator activated receptor signaling pathway +   
regulation of platelet-derived growth factor receptor signaling pathway +   
regulation of postsynapse to nucleus signaling pathway  
regulation of receptor signaling pathway via STAT +   
regulation of red or far-red light signaling pathway +  
regulation of retinoic acid receptor signaling pathway +   
regulation of Roundabout signaling pathway +  
regulation of salicylic acid mediated signaling pathway +  
regulation of semaphorin-plexin signaling pathway +   
regulation of sevenless signaling pathway +  
regulation of signal transduction +   
regulation of signal transduction by receptor internalization +   
regulation of signal transduction in response to host +  
regulation of signal transduction involved in conjugation with cellular fusion +  
regulation of signaling receptor activity +   
regulation of smoothened signaling pathway +   
regulation of sphingolipid mediated signaling pathway +   
regulation of SREBP signaling pathway +   
regulation of thyroid hormone mediated signaling pathway +   
regulation of Toll signaling pathway +   
regulation of toll-like receptor signaling pathway +   
regulation of torso signaling pathway +  
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +   
regulation of vascular endothelial growth factor receptor signaling pathway +   
regulation of vascular endothelial growth factor signaling pathway +   
regulation of vitamin D receptor signaling pathway +   
regulation of Wnt signaling pathway +   
salicylic acid mediated signaling pathway +  
signal clustering  
signal complex assembly  
signal transduction by conformational transition 
signal transduction by protein phosphorylation +   
signal transduction in absence of ligand +   
signal transduction involved in cellular response to ammonium ion +   
signal transduction involved in filamentous growth 
signal transduction involved in morphogenesis checkpoint 
signal transduction involved in positive regulation of conjugation with cellular fusion +  
signal transduction involved in regulation of aerobic respiration  
signal transduction involved in regulation of gene expression  
SMAD protein signal transduction +   
sphingolipid mediated signaling pathway +   

Synonyms
Exact Synonyms: down regulation of signal transduction ;   downregulation of signal transduction
Narrow Synonyms: inhibition of signal transduction
Related Synonyms: negative regulation of signaling pathway ;   negative regulation of signalling pathway
Alternate IDs: GO:0035467
Definition Sources: GOC:sm

paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.