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Ontology Browser

Term:
heparan sulfate proteoglycan biosynthetic process (GO:0015012)
Annotations: Rat: (23) Mouse: (22) Human: (26) Chinchilla: (25) Bonobo: (26) Dog: (19) Squirrel: (1) Pig: (20)
Parent Terms Term With Siblings Child Terms
chondroitin sulfate proteoglycan biosynthetic process +   
dermatan sulfate proteoglycan biosynthetic process +   
heparan sulfate proteoglycan biosynthetic process +   
The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
heparan sulfate proteoglycan biosynthetic process, enzymatic modification  
heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 
heparan sulfate proteoglycan catabolic process  
negative regulation of proteoglycan biosynthetic process 
positive regulation of proteoglycan biosynthetic process +   

Synonyms
Exact Synonyms: heparan sulfate proteoglycan anabolism ;   heparan sulfate proteoglycan biosynthesis ;   heparan sulfate proteoglycan formation ;   heparan sulfate proteoglycan synthesis ;   heparan sulphate proteoglycan biosynthesis ;   heparan sulphate proteoglycan biosynthetic process
Related Synonyms: heparin proteoglycan biosynthetic process
Xrefs: RESID:AA0210
Definition Sources: GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.