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Ontology Browser

Parent Terms Term With Siblings Child Terms
autophagy +     
autophagy of mitochondrion +   
autophagy of nucleus +   
autophagy of peroxisome +   
chaperone-mediated autophagy +   
late endosomal microautophagy  
lysosomal microautophagy +   
macroautophagy +   
The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
negative regulation of autophagy +   
positive regulation of autophagy +   
protein targeting to vacuole involved in autophagy +   
regulation of autophagy +   

Broad Synonyms: autophagy
Alternate IDs: GO:0034262
Definition Sources: PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.