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Ontology Browser

Parent Terms Term With Siblings Child Terms
gene silencing by miRNA +   
RNA interference +   
The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.

Exact Synonyms: RNAi ;   posttranscriptional gene silencing by siRNA
Xrefs: Wikipedia:RNA_interference
Never In Taxon: NCBITaxon:4895 ! Schizosaccharomyces
Definition Sources: GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.