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Term:
2-oxoglutarate-dependent dioxygenase activity (GO:0016706)
Annotations: Rat: (49) Mouse: (49) Human: (47) Chinchilla: (46) Bonobo: (45) Dog: (38) Squirrel: (45) Pig: (41)
Parent Terms Term With Siblings Child Terms
1,2-dihydroxynaphthalene dioxygenase activity 
1-hydroxypyrene 6,7-monooxygenase activity 
1-hydroxypyrene 7,8-monooxygenase activity 
1-methoxypyrene 6,7-monooxygenase activity 
11-cis-retinal 3,4-desaturase activity  
11alpha-30-dihydroxy beta-amyrin dehydrogenase activity 
2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity 
2,6-dihydroxybenzothiazole monooxygenase activity 
2-(methylthio)benzothiazole monooxygenase activity 
2-hydroxybenzothiazole monooxygenase activity 
2-hydroxyisobutyrate 3-monooxygenase activity 
2-hydroxypyridine 5-monooxygenase activity 
2-octaprenyl-6-methoxyphenol hydroxylase activity 
2-oxoglutarate-dependent dioxygenase activity +   
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
25-hydroxycholecalciferol-24-hydroxylase activity  
3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity 
3-butenylglucosinolate 2-hydroxylase activity 
3-hydroxybenzoate 2-monooxygenase activity 
3-methylthiopropyl glucosinolate S-oxygenase activity 
4-(1-ethyl-1,4-dimethyl-pentyl)phenol monooxygenase activity 
4-chloro-allylglycine synthase activity 
4-chlorophenoxyacetate monooxygenase activity 
4-methoxybenzoate monooxygenase (O-demethylating) activity 
4-methylthiopropyl glucosinolate S-oxygenase activity 
4-nitrocatechol 4-monooxygenase activity 
5-methylthiopropyl glucosinolate S-oxygenase activity 
6-deoxocathasterone hydroxylase activity 
6-deoxotyphasterol C-23 hydroxylase activity 
6-methylthiopropyl glucosinolate S-oxygenase activity 
7-methylthiopropyl glucosinolate S-oxygenase activity 
8-methylthiopropyl glucosinolate S-oxygenase activity 
9-fluorenone-3,4-dioxygenase activity 
all-trans retinal 3,4-desaturase activity  
all-trans retinoic acid 3,4-desaturase activity  
all-trans retinol 3,4-desaturase activity  
alpha-ketoglutarate-dependent xanthine dioxygenase activity 
alpha-pinene dehydrogenase activity 
alpha-pinene monooxygenase activity 
ammonia monooxygenase activity 
amorpha-4,11-diene 12-monooxygenase activity 
androst-4-ene-3,17-dione monooxygenase activity 
anthracene 9,10-dioxygenase activity 
arachidonic acid monooxygenase activity +   
averantin hydroxylase activity 
benzo(a)pyrene 11,12-epoxidase activity 
benzothiazole monooxygenase activity 
betulin dehydrogenase activity 
bisphenol A hydroxylase B activity 
carotene 7,8-desaturase activity 
carotene epsilon hydroxylase activity +  
cathasterone hydroxylase activity 
cholesterol 25-hydroxylase activity  
coumarin 7-hydroxylase activity  
DDT 2,3-dioxygenase activity 
delta 3-trans-hexadecenoic acid phosphatidylglycerol desaturase activity 
delta12-fatty acid dehydrogenase activity 
deoxyhypusine monooxygenase activity  
di-n-butyltin dioxygenase activity 
dibenzothiophene-5,5-dioxide monooxygenase activity 
dimethylsilanediol hydroxylase activity 
DOPA dioxygenase activity 
ecdysone 20-monooxygenase activity 
endosulfan ether monooxygenase activity 
endosulfan monooxygenase I activity 
estradiol 6-beta-monooxygenase activity 
estrogen 16-alpha-hydroxylase activity  
estrogen 2-hydroxylase activity  
fatty acid omega-hydroxylase activity 
fluorene oxygenase activity  
gamma-glutamyl hercynylcysteine sulfoxide synthase 
gibberellin A12 16alpha,17 epoxidase activity 
gibberellin A4 16alpha,17 epoxidase activity 
gibberellin A9 16alpha,17 epoxidase activity 
heme oxygenase (decyclizing) activity  
hercynylcysteine sulfoxide synthase 
hercynylselenocysteine synthase 
histone demethylase activity (H3-monomethyl-K4 specific)  
hydroxymethylsilanetriol oxidase activity 
juglone 3-monooxygenase activity 
kynurenine 7,8-hydroxylase activity 
labd-13Z-ene-9,15,16-triol synthase activity 
Latia-luciferin monooxygenase (demethylating) activity 
linalool 8-monooxygenase activity 
linoleic acid epoxygenase activity  
methyl tertiary butyl ether 3-monooxygenase activity 
methylcytosine to 5-glyceryl-methylcytosine dioxygenase activity 
methylsilanetriol hydroxylase activity 
mono-butyltin dioxygenase activity 
monoprenyl isoflavone epoxidase activity 
myristoyl-CoA 11-(E) desaturase activity 
myristoyl-CoA 11-(Z) desaturase activity 
N-nitrodimethylamine hydroxylase activity 
naphthalene disulfonate 1,2-dioxygenase activity 
naphthalene hydroxylase activity 
omega-3 fatty acid desaturase activity +  
omega-6 fatty acid desaturase activity  
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen +   
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen +   
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor +   
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen +   
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen +   
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen +   
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen +   
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated +  
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated +   
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water +   
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen +   
oxysterol 7-alpha-hydroxylase activity  
phenylboronic acid monooxygenase activity 
phylloquinone monooxygenase (2,3-epoxidizing) activity 
pinacolone 5-monooxygenase activity 
plasmanylethanolamine desaturase activity  
progesterone 11-alpha-monooxygenase activity 
progesterone monooxygenase activity 
prostaglandin-endoperoxide synthase activity  
pyrene 1,2-monooxygenase activity 
pyrene 4,5-monooxygenase activity 
retinoic acid 4-hydroxylase activity +   
spheroidene monooxygenase activity 
sphingolipid delta-4 desaturase activity  
sphingolipid delta-8 desaturase activity +  
steroid 17-alpha-monooxygenase activity  
steroid 21-monooxygenase activity  
steroid 7-alpha-hydroxylase activity  
steroid 9-alpha-monooxygenase activity 
sterol 12-alpha-hydroxylase activity  
sterol desaturase activity +   
taxadiene 5-alpha-hydroxylase activity 
tert-butanol 2-monooxygenase activity 
testosterone 15-alpha-hydroxylase activity 
testosterone 16-alpha-hydroxylase activity  
thioacetamide S-oxide S-oxygenase activity 
thioacetamide S-oxygenase activity 
thiophene-2-carbonyl-CoA monooxygenase activity 
tri-n-butyltin dioxygenase activity 
typhasterol C-23 hydroxylase activity 
uvaol dehydrogenase activity 

Synonyms
Exact Synonyms: 2-oxoglutarate dioxygenase activity ;   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Alternate IDs: GO:0010302
Xrefs: EC:1.14.11 ;   Reactome:R-HSA-1234164 "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A)" ;   reactome:R-HSA-6783455 "TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe)"
Definition Sources: GOC:mah

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.