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ammonia assimilation cycle (GO:0019676)
Annotations: Rat: (3) Mouse: (3) Human: (3) Chinchilla: (3) Bonobo: (3) Dog: (3) Squirrel: (3)
Parent Terms Term With Siblings Child Terms
ammonia assimilation cycle +   
The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen.
arginine catabolic process to glutamate  
cyclization of glutamine involved in intein-mediated protein splicing 
D-glutamate metabolic process 
D-glutamine metabolic process 
glutamate biosynthetic process +   
glutamate catabolic process +   
glutamine biosynthetic process +   
glutamine catabolic process +   
histidine catabolic process to glutamate and formamide  
histidine catabolic process to glutamate and formate  
negative regulation of glutamate metabolic process +   
negative regulation of nitrogen utilization +  
peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamine 
positive regulation of glutamate metabolic process +   
positive regulation of nitrogen utilization +   
proline catabolic process to glutamate +   
regulation of glutamate metabolic process +   
regulation of nitrogen utilization +   
tetrapyrrole biosynthetic process from glutamate +   

Exact Synonyms: glutamate metabolic process via glutamine and ammonia ;   glutamate metabolism via glutamine and ammonia
Xrefs: MetaCyc:AMMASSIM-PWY ;   MetaCyc:PWY-3282
Definition Sources: MetaCyc:AMMASSIM-PWY

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