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Ontology Browser

Term:
ubiquitin-dependent ERAD pathway (GO:0030433)
Annotations: Rat: (75) Mouse: (75) Human: (80) Chinchilla: (78) Bonobo: (78) Dog: (67) Squirrel: (1) Pig: (67)
Parent Terms Term With Siblings Child Terms
anaphase-promoting complex-dependent catabolic process +   
cytoplasm protein quality control by the ubiquitin-proteasome system  
ER-associated misfolded protein catabolic process  
maintenance of unfolded protein involved in ERAD pathway  
mitochondria-associated ubiquitin-dependent protein catabolic process  
negative regulation of ERAD pathway +   
negative regulation of proteasomal ubiquitin-dependent protein catabolic process +   
nuclear protein quality control by the ubiquitin-proteasome system +   
positive regulation of ERAD pathway +   
positive regulation of proteasomal ubiquitin-dependent protein catabolic process +   
protein localization to cytosolic proteasome complex involved in ERAD pathway  
regulation of ERAD pathway +   
regulation of proteasomal ubiquitin-dependent protein catabolic process +   
retrograde protein transport, ER to cytosol +   
ribosome-associated ubiquitin-dependent protein catabolic process  
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process +   
stress-induced homeostatically regulated protein degradation pathway 
transcription factor catabolic process +   
ubiquitin-dependent ERAD pathway +   
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
ubiquitin-dependent protein catabolic process via the N-end rule pathway  

Synonyms
Exact Synonyms: ER-associated ubiquitin-dependent protein breakdown ;   ER-associated ubiquitin-dependent protein catabolic process ;   ER-associated ubiquitin-dependent protein catabolism ;   ER-associated ubiquitin-dependent protein degradation ;   ERAD ;   endoplasmic reticulum-associated ubiquitin-dependent protein catabolic process ;   endoplasmic reticulum-associated ubiqutin-dependent protein catabolism ;   ubiquitin-dependent proteasomal protein catabolism of ER proteins
Definition Sources: GOC:mah, GOC:rb, PMID:14607247, PMID:19520858

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.