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Ontology Browser

Parent Terms Term With Siblings Child Terms
TOR complex +     
TORC1 complex  
TORC2 complex  
A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p.

Exact Synonyms: TOR complex 2 ;   TORC 2 complex ;   TORC2 ;   rapamycin and nutrient-insensitive TOR complex
Narrow Synonyms: mTORC2
Xrefs: Wikipedia:MTORC1
Definition Sources: GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.