Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

cytoplasm to vacuole transport by the Cvt pathway (GO:0032258)
Annotations: Rat: (3) Mouse: (3) Human: (3) Chinchilla: (2) Bonobo: (3) Dog: (2) Squirrel: (0) Pig: (3)
Parent Terms Term With Siblings Child Terms
autophagy +   
cytoplasm to vacuole transport by the Cvt pathway +   
A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast.
cytoplasm to vacuole transport by the NVT pathway 
protein targeting to lysosome +   
protein targeting to vacuolar membrane +   
protein targeting to vacuole involved in autophagy +   

Exact Synonyms: cytoplasm to vacuole targeting ;   protein localization by the Cvt pathway
Definition Sources: PMID:12865942, PMID:15659643

paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.