Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

Parent Terms Term With Siblings Child Terms
secretory granule +     
acrosomal vesicle +   
azurophil granule +   
chromaffin granule +   
clathrin-coated endocytic vesicle +   
clathrin-coated vesicle membrane +   
clathrin-sculpted vesicle +   
cortical granule  
dense core granule +   
ficolin-1-rich granule +   
insulin-responsive compartment  
lamellar body +   
mucin granule  
platelet alpha granule +   
platelet dense granule +   
secretory granule lumen +   
secretory granule membrane +   
specific granule +   
tertiary granule +   
trans-Golgi network transport vesicle +   
Weibel-Palade body  
A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses.
zymogen granule +   

Xrefs: Wikipedia:Weibel-Palade_body
Definition Sources: PMID:11935287, PMID:16087708

paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.