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Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
cytoplasmic pattern recognition receptor signaling pathway +   
endosomal signal transduction 
hippo signaling +   
The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.
I-kappaB kinase/NF-kappaB signaling +   
inositol lipid-mediated signaling +   
intracellular signal transduction involved in positive regulation of cell growth 
intrinsic apoptotic signaling pathway +   
MAPK cascade +   
negative regulation of intracellular signal transduction +   
NIK/NF-kappaB signaling +   
phosphorelay signal transduction system +   
PKR-mediated signaling 
positive regulation of intracellular signal transduction +   
protein kinase A signaling +   
protein kinase B signaling +   
protein kinase C signaling +   
protein kinase D signaling +   
RAM/MOR signaling pathway 
regulation of intracellular signal transduction +   
second-messenger-mediated signaling +   
signal transduction by p53 class mediator +   
signal transduction downstream of smoothened +   
signal transduction in response to DNA damage +   
signal transduction involved in cell cycle checkpoint +   
signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle 
small GTPase mediated signal transduction +   
stress-activated protein kinase signaling cascade +   
TOR signaling +   
TRAF-mediated signal transduction  

Synonyms
Exact Synonyms: hippo signal transduction ;   hippo signaling pathway
Narrow Synonyms: SWH pathway ;   Salvador-Warts-Hippo signaling pathway
Related Synonyms: hippo signaling cascade ;   hippo signalling cascade
Definition Sources: PMID:17318211, PMID:18328423

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.