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Ontology Browser

Term:
senescence-associated heterochromatin focus assembly (GO:0035986)
Annotations: Rat: (3) Mouse: (3) Human: (3) Chinchilla: (2) Bonobo: (3) Dog: (2) Squirrel: (2) Pig: (3)
Parent Terms Term With Siblings Child Terms
DNA methylation-dependent heterochromatin assembly +   
heterochromatin assembly by small RNA +   
heterochromatin domain assembly +  
heterochromatin island assembly +  
inactivation of X chromosome by heterochromatin assembly  
negative regulation of heterochromatin assembly +   
pericentric heterochromatin assembly +   
positive regulation of heterochromatin assembly +   
rDNA heterochromatin assembly +   
regulation of heterochromatin assembly +   
senescence-associated heterochromatin focus assembly  
The assembly of chromatin into senescence-associated heterochromatin foci (SAHF), transcriptionally-silent heterochromatin structures present in senescent cells, containing the condensed chromatin of one chromosome, and enriched for histone modifications. Formation of these chromatin structures is thought to repress expression of proliferation-promoting genes.
silent mating-type cassette heterochromatin assembly +  
subtelomeric heterochromatin assembly +   

Synonyms
Exact Synonyms: SAHF formation ;   senescence-associated heterochromatin foci formation ;   senescence-associated heterochromatin focus formation
Definition Sources: GOC:yaf, PMID:15621527, PMID:21248468

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.