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mediator complex binding (GO:0036033)
Annotations: Rat: (5) Mouse: (5) Human: (5) Chinchilla: (5) Bonobo: (5) Dog: (4) Squirrel: (0) Pig: (5)
Parent Terms Term With Siblings Child Terms
actin filament binding +   
activin binding  
anaphase-promoting complex binding  
AP-1 adaptor complex binding  
AP-2 adaptor complex binding  
AP-3 adaptor complex binding  
Arp2/3 complex binding  
BAT3 complex binding  
BBSome binding 
beta-catenin destruction complex binding  
BLOC-2 complex binding  
CCR4-NOT complex binding 
chloroplast photosystem I binding 
chloroplast photosystem II binding 
collagen binding +   
collagen fibril binding  
complement component C1q complex binding  
dynein complex binding  
exon-exon junction complex binding  
FACT complex binding 
Fc-gamma receptor I complex binding  
fibrinogen binding  
G-protein beta/gamma-subunit complex binding  
GARP complex binding  
GATOR1 complex binding 
Golgi transport complex binding 
heterotrimeric G-protein binding  
IkappaB kinase complex binding  
immunoglobulin binding +   
inhibin complex binding 
insulin receptor binding  
integrin binding +   
intermediate filament binding +   
intraciliary transport particle A binding  
intraciliary transport particle B binding  
MCM complex binding 
mediator complex binding  
Interacting selectively and non-covalently with a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
MHC protein complex binding +   
mismatch repair complex binding +   
mitochondrial proton-transporting ATP synthase complex binding  
mRNA cap binding complex binding  
MTREC complex binding 
nascent polypeptide-associated complex binding 
NuA4 histone acetyltransferase complex binding 
nucleosome binding +   
oligosaccharyltransferase complex binding  
P-TEFb complex binding  
PRC1 complex binding 
proteasome binding  
proteasome core complex binding  
proteasome regulatory particle binding  
protein-lipid complex binding +   
PSII associated light-harvesting complex II binding 
retromer complex binding  
ribonucleoprotein complex binding +   
SAGA complex binding 
SCF ubiquitin ligase complex binding 
Sec61 translocon complex binding  
spectrin binding  
Swi5-Sfr1 complex binding 
T cell receptor binding  
TAP complex binding  
TFIIA-class transcription factor complex binding 
TFIID-class transcription factor complex binding  
TFIIE-class transcription factor complex binding 
TFIIF-class transcription factor complex binding  
TFIIH-class transcription factor complex binding  
TORC2 complex binding  
transcription factor TFIIH holo complex binding 
TSC1-TSC2 complex binding  
type I interferon receptor binding  

Definition Sources: GOC:yaf, PMID:18391015

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.