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Term:
ATF6-mediated unfolded protein response (GO:0036500)
Annotations: Rat: (3) Mouse: (3) Human: (10) Chinchilla: (3) Bonobo: (3) Dog: (3) Squirrel: (2) Pig: (3)
Parent Terms Term With Siblings Child Terms
ATF6-mediated unfolded protein response +   
A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.
ER overload response +   
IRE1-mediated unfolded protein response +   
negative regulation of endoplasmic reticulum unfolded protein response +   
PERK-mediated unfolded protein response +   
positive regulation of endoplasmic reticulum unfolded protein response +   
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response  
regulation of endoplasmic reticulum unfolded protein response +   
SREBP signaling pathway +   

Synonyms
Exact Synonyms: ATF6 branch of UPR ;   UPR signaling by ATF6 stress sensor ;   activating transcription factor 6 signaling in unfolded protein response ;   endoplasmic reticulum unfolded protein response; ATF6 signaling
Narrow Synonyms: ATF6-alpha UPR branch ;   ATF6-beta UPR branch
Broad Synonyms: ATF6 signal transduction pathway
Related Synonyms: ATF6 signaling in response to endoplasmic reticulum stress
Definition Sources: GOC:bf, GOC:PARL, PMID:22013210

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.