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Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
cellular response to organonitrogen compound +   
endoplasmic reticulum stress-induced pre-emptive quality control  
endoplasmic reticulum unfolded protein response +   
ER overload response +   
ERAD pathway +   
The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +   
negative regulation of proteasomal protein catabolic process +   
negative regulation of response to endoplasmic reticulum stress +   
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  
positive regulation of proteasomal protein catabolic process +   
positive regulation of response to endoplasmic reticulum stress +   
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  
proteasomal ubiquitin-independent protein catabolic process  
proteasome-mediated ubiquitin-dependent protein catabolic process +   
regulation of proteasomal protein catabolic process +   
regulation of response to endoplasmic reticulum stress +   
regulation of translation in response to endoplasmic reticulum stress +   
response to (R)-carnitine  
response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine +   
response to 4-nitroquinoline N-oxide +  
response to 5-fluoro-2'-deoxyuridine 
response to acadesine +  
response to acrylamide +   
response to alkaloid +   
response to amiloride +  
response to amine +   
response to amino acid +   
response to amitrole +  
response to anisomycin +   
response to antimycin A +  
response to benomyl +   
response to biotin +   
response to candesartan  
response to capsazepine +   
response to carbendazim +  
response to CCCP +  
response to chitin +  
response to chloramphenicol +  
response to chloroquine +   
response to chondroitin 4'-sulfate +  
response to chondroitin 6'-sulfate +  
response to ciliary neurotrophic factor +   
response to clopidogrel 
response to clozapine  
response to cobalamin +   
response to cycloheximide +   
response to cyclophosphamide 
response to cytarabine 
response to cytochalasin B +   
response to desipramine +   
response to diphenidol +  
response to folic acid +   
response to gemcitabine 
response to glycoprotein +   
response to haloperidol +  
response to heparin +   
response to histamine +   
response to imidacloprid 
response to indole-3-methanol +   
response to indolebutyric acid +  
response to ketamine  
response to L-phenylalanine derivative +   
response to lapatinib 
response to latrunculin A +  
response to latrunculin B +  
response to lipoprotein particle +   
response to manganese-induced endoplasmic reticulum stress  
response to metformin  
response to methotrexate +   
response to miconazole +  
response to monoamine +   
response to nocodazole +  
response to olanzapine 
response to paracetamol  
response to peptide +   
response to peptidoglycan +   
response to perphenazine 
response to polyamine macromolecule +  
response to purine-containing compound +   
response to putrescine +   
response to pyrimidine ribonucleotide +   
response to quetiapine 
response to rapamycin +   
response to ribavirin 
response to risperidone 
response to temozolomide 
response to tetrahydrofolate +   
response to thiabendazole +  
response to trichostatin A +   
response to vitamin B1 +   
response to vitamin B2 +   
response to vitamin B6 +   
response to ximelagatran 
response to ziprasidone 
stress-induced homeostatically regulated protein degradation pathway 

Synonyms
Exact Synonyms: endoplasmic reticulum-associated degradation ;   protein degradation by ERAD
Related Synonyms: ER-associated degradation pathway ;   endoplasmic reticulum-associated protein degradation pathway
Definition Sources: GOC:bf, GOC:PARL, PMID:20940304, PMID:21969857

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.