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Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
cytoplasmic pattern recognition receptor signaling pathway +   
endosomal signal transduction 
hippo signaling +   
I-kappaB kinase/NF-kappaB signaling +   
inositol lipid-mediated signaling +   
intracellular signal transduction involved in positive regulation of cell growth 
intrinsic apoptotic signaling pathway +   
MAPK cascade +   
negative regulation of intracellular signal transduction +   
NIK/NF-kappaB signaling +   
The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).
phosphorelay signal transduction system +   
PKR-mediated signaling 
positive regulation of intracellular signal transduction +   
protein kinase A signaling +   
protein kinase B signaling +   
protein kinase C signaling +   
protein kinase D signaling +   
RAM/MOR signaling pathway 
regulation of intracellular signal transduction +   
second-messenger-mediated signaling +   
signal transduction by p53 class mediator +   
signal transduction downstream of smoothened +   
signal transduction in response to DNA damage +   
signal transduction involved in cell cycle checkpoint +   
signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle 
small GTPase mediated signal transduction +   
stress-activated protein kinase signaling cascade +   
TOR signaling +   
TRAF-mediated signal transduction  

Synonyms
Exact Synonyms: NIK/NF-kappaB signal transduction
Narrow Synonyms: p52-dependent NF-kappaB signaling
Broad Synonyms: non-canonical NF-KB signaling ;   noncanonical NF-kappaB signaling ;   noncanonical nuclear factor kappaB (NF-kappaB) pathway
Related Synonyms: NIK/NF-kappaB cascade
Definition Sources: GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.