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Term:
cytoplasmic pattern recognition receptor signaling pathway in response to virus (GO:0039528)
Annotations: Rat: (30) Mouse: (29) Human: (34) Chinchilla: (29) Bonobo: (29) Dog: (28) Squirrel: (29) Pig: (29)
Parent Terms Term With Siblings Child Terms
antiviral innate immune response  
cytoplasmic pattern recognition receptor signaling pathway in response to virus +   
Any series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
negative regulation of defense response to virus +   
nucleotide-binding oligomerization domain containing signaling pathway +   
phage shock 
positive regulation by virus of host cytokine production 
positive regulation of chemokine production +   
positive regulation of connective tissue growth factor production  
positive regulation of cytokine biosynthetic process +   
positive regulation of cytokine production involved in immune response +   
positive regulation of cytokine production involved in inflammatory response  
positive regulation of cytokine secretion +   
positive regulation of endothelin production  
positive regulation of fibroblast growth factor production  
positive regulation of granulocyte macrophage colony-stimulating factor production +   
positive regulation of hepatocyte growth factor production +  
positive regulation of interferon-gamma production  
positive regulation of interleukin-1 production +   
positive regulation of interleukin-10 production  
positive regulation of interleukin-11 production 
positive regulation of interleukin-12 production  
positive regulation of interleukin-13 production  
positive regulation of interleukin-14 production 
positive regulation of interleukin-15 production  
positive regulation of interleukin-16 production  
positive regulation of interleukin-17 production +   
positive regulation of interleukin-18 production  
positive regulation of interleukin-19 production 
positive regulation of interleukin-2 production  
positive regulation of interleukin-20 production 
positive regulation of interleukin-21 production 
positive regulation of interleukin-22 production 
positive regulation of interleukin-23 production  
positive regulation of interleukin-24 production 
positive regulation of interleukin-25 production 
positive regulation of interleukin-26 production 
positive regulation of interleukin-27 production 
positive regulation of interleukin-3 production  
positive regulation of interleukin-32 production 
positive regulation of interleukin-33 production  
positive regulation of interleukin-34 production 
positive regulation of interleukin-35 production 
positive regulation of interleukin-37 production 
positive regulation of interleukin-4 production  
positive regulation of interleukin-5 production  
positive regulation of interleukin-6 production  
positive regulation of interleukin-7 production 
positive regulation of interleukin-8 production  
positive regulation of interleukin-9 production 
positive regulation of macrophage colony-stimulating factor production +   
positive regulation of MDA-5 signaling pathway  
positive regulation of platelet-derived growth factor production  
positive regulation of RIG-I signaling pathway  
positive regulation of transforming growth factor beta production +   
positive regulation of tumor necrosis factor superfamily cytokine production +   
positive regulation of type I interferon production +   
positive regulation of type III interferon production  
positive regulation of vascular endothelial growth factor production  
regulation of defense response to virus +   
suppression by virus of host cell lysis in response to superinfection 
virus induced gene silencing +  

Synonyms
Exact Synonyms: cytoplasmic pattern recognition receptor signalling pathway in response to virus ;   virus-induced cytoplasmic pattern recognition receptor signaling pathway
Narrow Synonyms: RIG-I-like receptor (RLR) signaling pathway ;   RIG-I/MDA5 signaling pathway ;   RIG-like helicase signaling pathway ;   RIG-like receptor signaling pathway ;   RLH signaling pathway ;   RLR signaling pathway ;   cytoplasmic caspase-recruiting domain (CARD) helicase signaling pathway
Definition Sources: GOC:bf, PMID:17328678, PMID:18272355, PMID:19531363

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.