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Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
MDA-5 signaling pathway +   
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +   
regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +   
RIG-I signaling pathway +   
Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. RIG-I detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.

Synonyms
Exact Synonyms: DDX58 signaling pathway ;   RIG-I signalling pathway ;   retinoic acid inducible gene I signaling pathway
Definition Sources: GOC:bf, PMID:17328678, PMID:19620789, PMID:21435580

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.