Ontology Browser

Term:
MDA-5 signaling pathway (GO:0039530)
Annotations: Rat: (7) Mouse: (7) Human: (10) Chinchilla: (9) Bonobo: (9) Dog: (9) Squirrel: (9)
Parent Terms Term With Siblings Child Terms
MDA-5 signaling pathway +   
Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. MDA-5 detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +   
regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +   
RIG-I signaling pathway +   

Synonyms
Exact Synonyms: IFIH1 signaling pathway ;   MDA-5 signalling pathway ;   melanoma differentiation-associated gene 5 signaling pathway
Narrow Synonyms: MDA5 signaling pathway
Definition Sources: GOC:bf, PMID:19620789

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.