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Term:
PKR-mediated signaling (GO:0039585)
Annotations: Rat: (0) Mouse: (0) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0)
Parent Terms Term With Siblings Child Terms
cytoplasmic pattern recognition receptor signaling pathway +   
endosomal signal transduction 
GCN2-mediated signaling 
hippo signaling +   
HRI-mediated signaling  
I-kappaB kinase/NF-kappaB signaling +   
inositol lipid-mediated signaling +   
intracellular signal transduction involved in positive regulation of cell growth 
intrinsic apoptotic signaling pathway +   
MAPK cascade +   
negative regulation of intracellular signal transduction +   
NIK/NF-kappaB signaling +   
PERK-mediated unfolded protein response +   
phosphorelay signal transduction system +   
PKR-mediated signaling 
A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR (also known as EIF2AK3), an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation.
positive regulation of intracellular signal transduction +   
protein kinase A signaling +   
protein kinase B signaling +   
protein kinase C signaling +   
protein kinase D signaling +   
RAM/MOR signaling pathway 
regulation of intracellular signal transduction +   
second-messenger-mediated signaling +   
signal transduction by p53 class mediator +   
signal transduction downstream of smoothened +   
signal transduction in response to DNA damage +   
signal transduction involved in cell cycle checkpoint +   
signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle 
small GTPase mediated signal transduction +   
stress-activated protein kinase signaling cascade +   
TOR signaling +   
TRAF-mediated signal transduction  

Synonyms
Exact Synonyms: EIF2AK3 signal transduction ;   EIF2AK3/PERK signaling ;   PKR signal transduction ;   PKR signaling pathway ;   signaling through PKR
Definition Sources: PMID:21204021, PMID:22102852, PMID:27629041, PMID:9843495, VZ:1576

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.