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Term:
negative regulation of tumor necrosis factor biosynthetic process (GO:0042536)
Annotations: Rat: (6) Mouse: (6) Human: (7) Chinchilla: (6) Bonobo: (6) Dog: (2) Squirrel: (0) Pig: (3)
Parent Terms Term With Siblings Child Terms
negative regulation of chemokine biosynthetic process +   
negative regulation of connective tissue growth factor biosynthetic process 
negative regulation of cytokine biosynthetic process involved in immune response 
negative regulation of granulocyte macrophage colony-stimulating factor biosynthetic process 
negative regulation of hepatocyte growth factor biosynthetic process  
negative regulation of interferon-alpha biosynthetic process  
negative regulation of interferon-beta biosynthetic process  
negative regulation of interferon-gamma biosynthetic process  
negative regulation of interleukin-1 biosynthetic process +  
negative regulation of interleukin-10 biosynthetic process  
negative regulation of interleukin-11 biosynthetic process 
negative regulation of interleukin-12 biosynthetic process  
negative regulation of interleukin-13 biosynthetic process 
negative regulation of interleukin-14 biosynthetic process 
negative regulation of interleukin-15 biosynthetic process 
negative regulation of interleukin-16 biosynthetic process 
negative regulation of interleukin-17 biosynthetic process +  
negative regulation of interleukin-18 biosynthetic process 
negative regulation of interleukin-19 biosynthetic process 
negative regulation of interleukin-2 biosynthetic process  
negative regulation of interleukin-20 biosynthetic process 
negative regulation of interleukin-21 biosynthetic process 
negative regulation of interleukin-22 biosynthetic process 
negative regulation of interleukin-23 biosynthetic process 
negative regulation of interleukin-24 biosynthetic process 
negative regulation of interleukin-26 biosynthetic process 
negative regulation of interleukin-27 biosynthetic process 
negative regulation of interleukin-3 biosynthetic process 
negative regulation of interleukin-35 biosynthetic process 
negative regulation of interleukin-4 biosynthetic process  
negative regulation of interleukin-5 biosynthetic process 
negative regulation of interleukin-6 biosynthetic process  
negative regulation of interleukin-7 biosynthetic process 
negative regulation of interleukin-8 biosynthetic process  
negative regulation of interleukin-9 biosynthetic process 
negative regulation of lymphotoxin A biosynthetic process 
negative regulation of TRAIL biosynthetic process 
negative regulation of tumor necrosis factor biosynthetic process  
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
negative regulation of tumor necrosis factor secretion  
positive regulation of tumor necrosis factor biosynthetic process  
regulation of tumor necrosis factor biosynthetic process +   

Synonyms
Exact Synonyms: down regulation of tumor necrosis factor biosynthetic process ;   downregulation of tumor necrosis factor biosynthetic process ;   negative regulation of TNF alpha biosynthesis ;   negative regulation of TNF alpha biosynthetic process ;   negative regulation of TNF biosynthesis ;   negative regulation of TNF biosynthetic process ;   negative regulation of tumor necrosis factor anabolism ;   negative regulation of tumor necrosis factor biosynthesis ;   negative regulation of tumor necrosis factor formation ;   negative regulation of tumor necrosis factor synthesis ;   negative regulation of tumor necrosis factor-alpha biosynthesis ;   negative regulation of tumor necrosis factor-alpha biosynthetic process
Narrow Synonyms: inhibition of tumor necrosis factor biosynthetic process
Definition Sources: GOC:jl, PMID:10891884

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.