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Ontology Browser

Term:
negative regulation of MAPK cascade (GO:0043409)
Annotations: Rat: (181) Mouse: (172) Human: (170) Chinchilla: (162) Bonobo: (162) Dog: (99) Squirrel: (2) Pig: (117)
Parent Terms Term With Siblings Child Terms
ERK1 and ERK2 cascade +   
ERK5 cascade +   
MAPK cascade involved in ascospore formation 
MAPK cascade involved in axon regeneration +  
MAPK cascade involved in innate immune response 
negative regulation of calcium-mediated signaling +   
negative regulation of cAMP-mediated signaling +   
negative regulation of cGMP-mediated signaling  
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  
negative regulation of hippo signaling  
negative regulation of histone phosphorylation +   
negative regulation of I-kappaB kinase/NF-kappaB signaling +   
negative regulation of I-kappaB phosphorylation  
negative regulation of inhibitory G protein-coupled receptor phosphorylation 
negative regulation of intrinsic apoptotic signaling pathway +   
negative regulation of MAPK cascade +   
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
negative regulation of NIK/NF-kappaB signaling  
negative regulation of nitric oxide mediated signal transduction  
negative regulation of nucleotide-binding oligomerization domain containing signaling pathway +   
negative regulation of pathway-restricted SMAD protein phosphorylation  
negative regulation of peptidyl-serine phosphorylation +   
negative regulation of peptidyl-threonine phosphorylation  
negative regulation of peptidyl-tyrosine phosphorylation +   
negative regulation of phosphatidylinositol 3-kinase signaling  
negative regulation of phosphorelay signal transduction system +  
negative regulation of phosphorylation of RNA polymerase II C-terminal domain +  
negative regulation of protein autophosphorylation +   
negative regulation of protein kinase activity +   
negative regulation of protein kinase B signaling  
negative regulation of protein kinase C signaling  
negative regulation of protein kinase D signaling 
negative regulation of signal transduction by p53 class mediator +   
negative regulation of signal transduction involved in mitotic G2 DNA damage checkpoint 
negative regulation of small GTPase mediated signal transduction +   
negative regulation of stress-activated protein kinase signaling cascade +   
negative regulation of TOR signaling +   
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +   
pheromone response MAPK cascade +  
positive regulation of MAPK cascade +   
regulation of ERK1 and ERK2 cascade +   
regulation of ERK5 cascade +   
regulation of MAP kinase activity +   
regulation of MAPK cascade +   
regulation of MAPK cascade involved in axon regeneration +  
regulation of stress-activated MAPK cascade +   
stress-activated MAPK cascade +   
suppression by virus of host protein phosphorylation +  

Synonyms
Exact Synonyms: down regulation of MAPK cascade ;   down regulation of MAPKKK cascade ;   downregulation of MAPK cascade ;   downregulation of MAPKKK cascade ;   negative regulation of MAP kinase cascade ;   negative regulation of MAP kinase kinase kinase cascade ;   negative regulation of MAPKKK cascade ;   negative regulation of mitogen activated protein kinase cascade ;   negative regulation of mitogen activated protein kinase kinase kinase cascade
Narrow Synonyms: inhibition of MAPK cascade ;   inhibition of MAPKKK cascade
Definition Sources: GOC:go_curators

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.