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Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
DNA polymerase III, beta sliding clamp processivity factor complex 
PCNA complex  
A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.

Synonyms
Exact Synonyms: PCNA homotrimer ;   proliferating cell nuclear antigen complex
Broad Synonyms: sliding clamp
Definition Sources: GOC:jl, PMID:12829735

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.