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Ontology Browser

Term:
intermediate filament polymerization (GO:0045107)
Annotations: Rat: (0) Mouse: (0) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0)
Parent Terms Term With Siblings Child Terms
actin filament polymerization +   
dynamin family protein polymerization involved in membrane fission +   
free ubiquitin chain polymerization +   
intermediate filament depolymerization +   
intermediate filament polymerization +  
Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain.
microtubule polymerization +   
negative regulation of protein polymerization +   
positive regulation of protein polymerization +   
regulation of intermediate filament polymerization or depolymerization +   
regulation of protein polymerization +   

Synonyms
Definition Sources: GOC:mah, PMID:8776884

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.