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hepoxilin A3 synthase activity (GO:0051120)
Annotations: Rat: (2) Mouse: (2) Human: (2) Chinchilla: (2) Bonobo: (2) Dog: (2) Squirrel: (2) Pig: (2)
Parent Terms Term With Siblings Child Terms
isomerase activity +     
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity 
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity 
cis-trans isomerase activity +   
dihydroneopterin triphosphate 2'-epimerase activity 
DNA topoisomerase activity +   
eoxin A4 synthase activity 
hepoxilin A3 synthase activity  
Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3.
hexulose-6-phosphate isomerase activity 
intramolecular lyase activity +   
intramolecular oxidoreductase activity +   
intramolecular transferase activity +   
N-acylmannosamine-6-phosphate 2-epimerase activity 
peroxynitrite isomerase activity  
racemase and epimerase activity +   
RNA topoisomerase activity 
S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity 
sulfoquinovose isomerase activity 
thiocyanate isomerase activity 

Xrefs: reactome:R-HSA-2161794 "Arachidonic acid is converted to HXA3/B3 by ALOX12" ;   reactome:R-HSA-8942208 "ALOXE3 isomerises 12R-HpETE to HXA3"
Definition Sources: PMID:15123652

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.