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Ontology Browser

Term:
canonical Wnt signaling pathway (GO:0060070)
Annotations: Rat: (293) Mouse: (294) Human: (360) Chinchilla: (258) Bonobo: (263) Dog: (292) Squirrel: (263) Pig: (288)
Parent Terms Term With Siblings Child Terms
canonical Wnt signaling pathway +   
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
negative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway 
negative regulation of Wnt signaling pathway +   
non-canonical Wnt signaling pathway +   
positive regulation of posterior neural plate formation by Wnt signaling pathway 
positive regulation of Wnt signaling pathway +   
regulation of Wnt signaling pathway +   
Wnt signaling pathway involved in animal/vegetal axis specification 
Wnt signaling pathway involved in digestive tract morphogenesis +   
Wnt signaling pathway involved in dorsal/ventral axis specification +   
Wnt signaling pathway involved in forebrain neuroblast division  
Wnt signaling pathway involved in heart development +   
Wnt signaling pathway involved in kidney development +   
Wnt signaling pathway involved in mammary gland specification 
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation +   
Wnt signaling pathway involved in primitive streak formation 
Wnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord 
Wnt signaling pathway involved in somitogenesis  
Wnt signaling pathway involved in wound healing, spreading of epidermal cells 
Wnt-activated signaling pathway involved in forebrain neuron fate commitment 

Synonyms
Exact Synonyms: Wnt receptor signaling pathway through beta-catenin ;   Wnt receptor signaling pathway via beta-catenin ;   Wnt receptor signalling pathway through beta-catenin ;   canonical Wnt receptor signaling pathway ;   canonical Wnt-activated signaling pathway
Narrow Synonyms: frizzled-1 receptor signaling pathway
Definition Sources: GOC:bf, GOC:dph, PMID:11532397, PMID:19619488

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.