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Ontology Browser

Term:
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment (GO:0061317)
Annotations: Rat: (4) Mouse: (3) Human: (4) Chinchilla: (4) Bonobo: (4) Dog: (2) Squirrel: (0) Pig: (3)
Parent Terms Term With Siblings Child Terms
atrial cardiac muscle cell fate commitment 
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment +   
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin and contributing to cardiac muscle cell fate commitment. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development  
canonical Wnt signaling pathway involved in positive regulation of cardiac muscle cell proliferation 
canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation  
canonical Wnt signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation 
cardiac muscle cell fate determination 
cardiac pacemaker cell fate commitment +   
negative regulation of canonical Wnt signaling pathway involved in heart development +   
negative regulation of heart induction by canonical Wnt signaling pathway  
positive regulation of canonical Wnt signaling pathway involved in heart development +   
regulation of canonical Wnt signaling pathway involved in heart development +   
ventricular cardiac muscle cell fate commitment 

Synonyms
Exact Synonyms: canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment ;   canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment ;   canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment
Definition Sources: GOC:mtg_heart, PMID:17576928

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.