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Ontology Browser

Parent Terms Term With Siblings Child Terms
Ire1 complex  
Las1 complex  
ribonuclease III complex +   
ribonuclease P complex +   
RISC-loading complex  
A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.
tRNA-intron endonuclease complex  

Exact Synonyms: miRLC ;   microRNA loading complex
Related Synonyms: RLC
Definition Sources: GOC:ab, GOC:BHF, GOC:nc, GOC:rph, PMID:18178619, PMID:19820710

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.