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Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
autophagosome membrane +   
contractile vacuolar membrane +  
EGO complex  
extrinsic component of vacuolar membrane +   
high-affinity iron exporter complex 
intrinsic component of vacuolar membrane +   
lytic vacuole membrane +   
PAS complex  
A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.
phosphatidylinositol 3-kinase complex, class III, type I  
phosphatidylinositol 3-kinase complex, class III, type II  
plant-type vacuole membrane +  
vacuolar HOPS complex +  
vacuolar proton-transporting V-type ATPase complex +   

Synonyms
Related Synonyms: autophagy-specific phosphatidylinositol 3-kinase complex
Definition Sources: PMID:18950639, PMID:19037259, PMID:19158662

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.