Ontology Browser

Term:
hypoxia-inducible factor-1alpha signaling pathway (GO:0097411)
Annotations: Rat: (7) Mouse: (7) Human: (5) Chinchilla: (5) Bonobo: (5) Dog: (5) Squirrel: (5)
Parent Terms Term With Siblings Child Terms
apoptotic signaling pathway +   
bile acid signaling pathway +   
calmodulin dependent kinase signaling pathway +   
carbohydrate mediated signaling +   
cell surface receptor signaling pathway +   
chloroplast-nucleus signaling pathway 
defense response signaling pathway, resistance gene-dependent 
defense response signaling pathway, resistance gene-independent 
endoplasmic reticulum unfolded protein response +   
ER-nucleus signaling pathway +   
extracellular ATP signaling 
G protein-coupled receptor signaling pathway +   
hormone-mediated signaling pathway +   
hydrogen peroxide mediated signaling pathway +  
hypoxia-inducible factor-1alpha signaling pathway +   
A series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia.
immune response-regulating signaling pathway +   
intracellular receptor signaling pathway +   
intracellular signal transduction +   
intrinsic apoptotic signaling pathway in response to hypoxia +   
ligand-gated ion channel signaling pathway +  
lipoprotein particle mediated signaling +   
mitochondria-nucleus signaling pathway  
necroptotic signaling pathway  
negative regulation of cellular response to hypoxia +   
negative regulation of signal transduction +   
neuronal signal transduction +   
osmosensory signaling pathway +   
phototransduction +   
positive regulation of cellular response to hypoxia +   
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia  
positive regulation of signal transduction +   
postsynaptic signal transduction +   
presynaptic signal transduction +   
red or far-red light signaling pathway +   
regulation of blood pressure by chemoreceptor signaling pathway 
regulation of cellular response to hypoxia +   
regulation of floral organ abscission by signal transduction +  
regulation of signal transduction +   
regulation of transcription from RNA polymerase II promoter in response to hypoxia +   
salicylic acid mediated signaling pathway +  
serotonin receptor signaling pathway +   
signal transduction by conformational transition 
signal transduction by protein phosphorylation +   
signal transduction in absence of ligand +   
signal transduction involved in cellular response to ammonium ion +   
signal transduction involved in filamentous growth 
signal transduction involved in morphogenesis checkpoint 
signal transduction involved in positive regulation of conjugation with cellular fusion +  
signal transduction involved in regulation of aerobic respiration  
signal transduction involved in regulation of gene expression  
SMAD protein signal transduction +   
sphingolipid mediated signaling pathway +   

Synonyms
Exact Synonyms: HIF1alpha pathway ;   hypoxia-inducible factor signaling ;   hypoxia-inducible factor-1alpha signalling pathway
Definition Sources: GOC:bf, GOC:jc, http://www.sabiosciences.com/pathway.php?sn=HIF1Alpha_Pathway

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.