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Ontology Browser

Term:
ubiquitin-dependent glycoprotein ERAD pathway (GO:0097466)
Annotations: Rat: (4) Mouse: (5) Human: (4) Chinchilla: (4) Bonobo: (4) Dog: (3) Squirrel: (0) Pig: (2)
Parent Terms Term With Siblings Child Terms
cellular response to glycoprotein +   
elastin catabolic process +   
mannoprotein catabolic process 
negative regulation of ER-associated ubiquitin-dependent protein catabolic process  
O-sialoglycoprotein catabolic process 
positive regulation of ER-associated ubiquitin-dependent protein catabolic process  
protein deglycosylation involved in glycoprotein catabolic process +   
proteoglycan catabolic process +   
regulation of ER-associated ubiquitin-dependent protein catabolic process +   
response to Thyroid stimulating hormone +   
ubiquitin-dependent glycoprotein ERAD pathway +   
An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component.

Synonyms
Exact Synonyms: ER-associated glycoprotein degradation ;   glycoprotein ERAD ;   gpERAD
Broad Synonyms: misfolded or incompletely synthesized glycoprotein catabolic process
Definition Sources: GOC:al, GOC:bf, PMID:16079177

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.