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Term:
negative regulation of guanyl-nucleotide exchange factor activity (GO:1905098)
Annotations: Rat: (8) Mouse: (8) Human: (6) Chinchilla: (6) Bonobo: (6) Dog: (6) Squirrel: (6)
Parent Terms Term With Siblings Child Terms
desensitization of G protein-coupled receptor signaling pathway by arrestin  
negative regulation of 3'-UTR-mediated mRNA stabilization 
negative regulation of actin binding +   
negative regulation of action potential +   
negative regulation of apolipoprotein binding  
negative regulation of asexual reproduction +  
negative regulation of behavior +   
negative regulation of C-C chemokine binding  
negative regulation of cell killing +   
negative regulation of cellular process +   
negative regulation of cellular protein localization +   
negative regulation of circadian rhythm +   
negative regulation of cohesin unloading 
negative regulation of cytokine activity +   
negative regulation of developmental pigmentation +   
negative regulation of developmental process +   
negative regulation of DNA-binding transcription factor activity +   
negative regulation of dosage compensation by inactivation of X chromosome 
negative regulation of establishment of protein localization +   
negative regulation of establishment of RNA localization to telomere  
negative regulation of fibrinolysis  
negative regulation of growth +   
negative regulation of growth hormone activity 
negative regulation of GTPase activity  
negative regulation of guanyl-nucleotide exchange factor activity +   
Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity.
negative regulation of hemostasis +   
negative regulation of heparan sulfate proteoglycan binding 
negative regulation of immune system process +   
negative regulation of interphase mitotic telomere clustering 
negative regulation of intracellular mRNA localization +  
negative regulation of lipid localization +   
negative regulation of locomotion +   
negative regulation of long-term synaptic depression  
negative regulation of long-term synaptic potentiation  
negative regulation of maintenance of permeability of blood-brain barrier  
negative regulation of membrane depolarization +   
negative regulation of membrane hyperpolarization  
negative regulation of metabolic process +   
negative regulation of microtubule binding +   
negative regulation of mitotic telomere tethering at nuclear periphery 
negative regulation of multi-organism process +   
negative regulation of multicellular organismal process +   
negative regulation of nitrogen utilization +  
negative regulation of nuclear receptor transcription coactivator activity  
negative regulation of phosphorus utilization 
negative regulation of proteasome-activating ATPase activity 
negative regulation of protein homodimerization activity  
negative regulation of protein localization to cell-cell adherens junction 
negative regulation of protein localization to presynapse 
negative regulation of Ras GTPase binding +   
negative regulation of receptor binding +   
negative regulation of receptor localization to synapse  
negative regulation of reproductive process +   
negative regulation of response to stimulus +   
negative regulation of ribonucleoprotein complex localization +  
negative regulation of short-term synaptic potentiation  
negative regulation of signaling +   
negative regulation of sulfur utilization 
negative regulation of telomerase RNA localization to Cajal body 
negative regulation of transport +   
positive regulation of calcium ion binding 
positive regulation of chromatin binding +   
positive regulation of collagen binding  
positive regulation of DNA binding +   
positive regulation of ferrous iron binding  
positive regulation of GTP binding +   
positive regulation of guanyl-nucleotide exchange factor activity +   
positive regulation of heparan sulfate binding  
positive regulation of lipid binding 
positive regulation of polysome binding  
positive regulation of protein binding +   
positive regulation of RNA binding +   
regulation of Rho guanyl-nucleotide exchange factor activity +   

Synonyms
Exact Synonyms: down regulation of GDP-dissociation stimulator activity ;   down regulation of GDS ;   down regulation of GEF ;   down regulation of guanyl-nucleotide exchange factor activity ;   down regulation of guanyl-nucleotide release factor activity ;   down regulation of guanyl-nucleotide releasing factor ;   downregulation of GDP-dissociation stimulator activity ;   downregulation of GDS ;   downregulation of GEF ;   downregulation of guanyl-nucleotide exchange factor activity ;   downregulation of guanyl-nucleotide release factor activity ;   downregulation of guanyl-nucleotide releasing factor ;   negative regulation of GDP-dissociation stimulator activity ;   negative regulation of GDS ;   negative regulation of GEF ;   negative regulation of guanyl-nucleotide release factor activity ;   negative regulation of guanyl-nucleotide releasing factor
Narrow Synonyms: down regulation of GNRP ;   downregulation of GNRP ;   inhibition of GDP-dissociation stimulator activity ;   inhibition of GDS ;   inhibition of GEF ;   inhibition of GNRP ;   inhibition of guanyl-nucleotide exchange factor activity ;   inhibition of guanyl-nucleotide release factor activity ;   inhibition of guanyl-nucleotide releasing factor ;   negative regulation of GNRP
Definition Sources: GO_REF:0000059, GOC:TermGenie, PMID:20484009

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