Ontology Browser

Term:
intrinsic apoptotic signaling pathway in response to hypoxia (GO:1990144)
Annotations: Rat: (8) Mouse: (7) Human: (7) Chinchilla: (7) Bonobo: (7) Dog: (6) Squirrel: (7)
Parent Terms Term With Siblings Child Terms
hypoxia-inducible factor-1alpha signaling pathway +   
intrinsic apoptotic signaling pathway by p53 class mediator +   
intrinsic apoptotic signaling pathway in response to DNA damage +   
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +   
intrinsic apoptotic signaling pathway in response to hypoxia +   
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hypoxia (lowered oxygen tension). Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. The pathway ends when the execution phase of apoptosis is triggered.
intrinsic apoptotic signaling pathway in response to nitrosative stress +   
intrinsic apoptotic signaling pathway in response to osmotic stress +   
intrinsic apoptotic signaling pathway in response to oxidative stress +   
negative regulation of cellular response to hypoxia +   
negative regulation of intrinsic apoptotic signaling pathway +   
positive regulation of cellular response to hypoxia +   
positive regulation of intrinsic apoptotic signaling pathway +   
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia  
regulation of cellular response to hypoxia +   
regulation of intrinsic apoptotic signaling pathway +   
regulation of transcription from RNA polymerase II promoter in response to hypoxia +   

Synonyms
Definition Sources: GOC:BHF, GOC:mtg_apoptosis, GOC:rl, PMID:20436456

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.