Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
5-lipoxygenase complex 
activin receptor complex  
AP-type membrane coat adaptor complex +   
Asi complex 
Atg1/ULK1 kinase complex  
ATG2-ATG18 complex 
Bam protein complex 
carboxy-terminal domain protein kinase complex +   
cargo receptor complex +  
chaperone-mediated autophagy translocation complex  
chloroplast outer membrane translocon 
chloroplast thylakoid membrane protein complex +  
clathrin complex  
COPII vesicles tethering complex 
cyclin-dependent protein kinase holoenzyme complex +   
cytochrome o ubiquinol oxidase complex 
cytoplasmic side of endoplasmic reticulum membrane +   
DAPK1-calmodulin complex 
Derlin-1 retrotranslocation complex  
Derlin-1-VIMP complex  
DNA-dependent protein kinase complex  
dolichyl-phosphate-mannose-protein mannosyltransferase complex +  
Dsc E3 ubiquitin ligase complex 
EGO complex  
endoplasmic reticulum palmitoyltransferase complex +   
endoplasmic reticulum Sec complex +   
endosomal scaffold complex 
ER membrane protein complex  
ER ubiquitin ligase complex +   
ESCRT I complex  
ESCRT II complex  
ESCRT III complex  
ESCRT IV complex 
extrinsic component of endoplasmic reticulum membrane  
fatty acid elongase complex 
Gin4 complex 
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex  
GPI-anchor transamidase complex  
H-gal-GP complex 
HOPS complex +   
IkappaB kinase complex  
inner mitochondrial membrane protein complex +   
intrinsic component of endoplasmic reticulum membrane +   
Ire1 complex  
A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript.
IRE1-TRAF2-ASK1 complex  
Las1 complex  
lipopolysaccharide receptor complex  
lumenal side of endoplasmic reticulum membrane +   
mannan polymerase complex +  
membrane coat +   
meprin A complex  
MHC class I peptide loading complex +   
NAD(P)H dehydrogenase complex (plastoquinone) +  
NADH dehydrogenase complex +   
Nem1-Spo7 phosphatase complex  
nuclear membrane complex Bqt3-Bqt4 
nuclear membrane protein complex +   
oligosaccharyltransferase complex +   
outer membrane protein complex 
outer mitochondrial membrane protein complex +   
PAR polarity complex 
phosphatidylinositol 3-kinase complex +   
phospholamban complex 
phosphorylase kinase complex  
photosystem +  
photosystem I antenna complex 
photosystem I reaction center 
photosystem II antenna complex 
photosystem II oxygen evolving complex 
photosystem II reaction center 
phycobilisome 
plasma membrane protein complex +   
pore complex +   
pre-B cell receptor complex 
protein C inhibitor-acrosin complex 
protein kinase 5 complex  
proton-transporting ATP synthase, catalytic core +   
proton-transporting ATP synthase, central stalk +  
proton-transporting ATP synthase, stator stalk +   
proton-transporting two-sector ATPase complex +   
proton-transporting two-sector ATPase complex, catalytic domain +   
proton-transporting two-sector ATPase complex, proton-transporting domain +   
Ragulator complex  
respiratory chain complex +   
retromer complex +   
retromer, cargo-selective complex  
retromer, tubulation complex  
ribonuclease III complex +   
ribonuclease P complex +   
RISC-loading complex  
rough endoplasmic reticulum membrane +   
sarcoplasmic reticulum membrane +   
Sec62/Sec63 complex  
signal peptidase complex  
signal recognition particle receptor complex  
smooth endoplasmic reticulum membrane +   
SNARE complex +   
sodium ion-transporting two-sector ATPase complex +  
SREBP-SCAP complex 
SREBP-SCAP-Insig complex  
starch utilization system complex 
STING complex 
TAP complex  
Tapasin-ERp57 complex 
Tic complex 
Toc complex 
transforming growth factor beta ligand-receptor complex 
translocon complex +   
transmembrane transporter complex +   
tRNA-intron endonuclease complex  
UDP-N-acetylglucosamine transferase complex  
VCP-NPL4-UFD1 AAA ATPase complex  
Vps55/Vps68 complex 

Synonyms
Exact Synonyms: IRE1 dimer
Related Synonyms: ERN1 complex
Xrefs: IntAct:EBI-8872439
Definition Sources: GOC:bf, GOC:bhm, PMID:18191223, PMID:25437541

paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.